Evidence map›Paper›PMID 29671006›Full record

ArticleCancer immunology, immunotherapy : CII2018

Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APC

Paulina Akeus, Louis Szeponik, Filip Ahlmanner, Patrik Sundström, Samuel Alsén, Bengt Gustavsson, Tim Sparwasser, Sukanya Raghavan, Marianne Quiding-Järbrink

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  9. Review
  10. RNA Flow Cytometry for the Study of T Cell Metabolism.International journal of molecular sciences · 2021
    Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. YYFZBJS ameliorates colorectal cancer progression in ApcCell communication and signaling : CCS · 2020
    Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Paulina AkeusDepartment of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Box 435, 405 30, Gothenburg, Sweden. paulina.akeus@gu.se.
Louis SzeponikDepartment of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Box 435, 405 30, Gothenburg, Sweden.
Filip AhlmannerDepartment of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Box 435, 405 30, Gothenburg, Sweden.
Patrik SundströmDepartment of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Box 435, 405 30, Gothenburg, Sweden.
Samuel AlsénDepartment of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Box 435, 405 30, Gothenburg, Sweden.
Bengt GustavssonDepartment of Surgery, Institute of Clinical Sciences, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Tim SparwasserCentre for Experimental and Clinical Infection Research, Institute of Infection Immunology, Twincore, Hanover, Germany.
Sukanya RaghavanDepartment of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Box 435, 405 30, Gothenburg, Sweden.
Marianne Quiding-JärbrinkDepartment of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Box 435, 405 30, Gothenburg, Sweden.
University of Gothenburg · SECenter for Experimental and Clinical Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-infiltrating lymphocytes are crucial for anti-tumor immunity. We have previously shown that regulatory T cells (Treg) are able to reduce T-cell transendothelial migration in vitro and accumulation of effector T cells in intestinal tumors in vivo. Treg depletion also resulted in increased levels of the chemokines CXCL9 and CXCL10 specifically in the tumors. In this study, we investigated the mechanisms for Treg mediated suppression of T-cell migration into intestinal tumors in the APC

Indexed as

Cell MovementAdenocarcinomaAnimalsChemokine CXCL9Colonic NeoplasmsDisease Models, AnimalEndothelium, VascularFemaleHumansIntestinal NeoplasmsLymphocyte DepletionLymphocytes, Tumor-InfiltratingMaleMiceMice, Inbred C57BLReceptors, CXCR3Chemokine CXCL9CXCL9 protein, humanCXCR3 protein, humanReceptors, CXCR3APCmin/+Colon cancerCXCR3MigrationRegulatory T cells

Identifiers

PMID29671006
PMCPMC6006230
OpenAlexW2799534409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.