Evidence map›Paper›PMID 29670861›Full record

ArticleFrontiers in cellular and infection microbiology2018

The Cynomolgus Macaque Natural History Model of Pneumonic Tularemia for Predicting Clinical Efficacy Under the Animal Rule.

Tina Guina, Lynda L Lanning, Kristian S Omland, Mark S Williams, Larry A Wolfraim, Stephen P Heyse, Christopher R Houchens, Patrick Sanz, Judith A Hewitt

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Animal modelling with theMicrobiology (Reading, England) · 2025
    Article
  6. The immune response toFrontiers in microbiology · 2025
    Review
  7. Review
  8. Efficacy of Doxycycline and Ciprofloxacin for Treatment of Pneumonic Tularemia in Cynomolgus Macaques.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  9. Review
  10. Article
  11. Identification of an Attenuated Substrain ofPathogens (Basel, Switzerland) · 2021
    Article
  12. The Natural History of AerosolizedPathogens (Basel, Switzerland) · 2021
    Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Tina GuinaNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Lynda L LanningNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Kristian S OmlandMergus Analytics, LLC, Jericho, VT, United States.
Mark S WilliamsNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Larry A WolfraimNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Stephen P HeyseNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Christopher R HouchensBiomedical Advanced Research and Development Authority, Department of Health and Human Services, Washington, DC, United States.
Patrick SanzNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Judith A HewittNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
National Institutes of Health · USNational Institute of Allergy and Infectious Diseases · USBiomedical Advanced Research and Development Authority · USSystems Analytics (United States) · US

Funding

FIBRINOGEN-BINDING PROTEIN IN THE ADHERENCE OF S AUREUSR29AI030061 · NIAID · ROCKEFELLER UNIVERSITY · PI CHEUNG, AMBROSE L. · 1993 to 1997
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NIAID NIH HHS HHSN272201000003CNIAID NIH HHS HHSN272201500018CNIAID NIH HHS N01 AI030061NIAID NIH HHS Y01 AI007282
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Disease Models, AnimalAnimalsBody TemperatureFemaleFrancisella tularensisHumansMacaca fascicularisMalePneumoniaTreatment OutcomeTularemiaanimal modelAnimal Model QualificationAnimal Rulecynomolgus macaqueFrancisella tularensisnon-human primatepneumonic tularemia

Identifiers

PMID29670861
PMCPMC5893833
OpenAlexW2796357410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.