ArticleBrain and behavior2018
Thalamic functional connectivity and its association with behavioral performance in older age.
Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Temporal Probability-Guided Shifts in Temporal Preparation Away from the Beat Under a Distracting Rhythm in Aging.Behavioral sciences (Basel, Switzerland) · 2026Article
- Prenatal Cannabis Exposure Shaping Altered Brain Connectivity: Neural Correlates of Cognitive and Mental Health Variability in Offspring.Research square · 2026Article
- Different structural brain patterns and their association with executive function and general cognitive ability in cognitively normal elderly adults.Frontiers in aging neuroscience · 2026Article
- Sex differences in the neuroimmune response following heavy, binge-like alcohol exposure in adolescent rats.Journal of neuroimmunology · 2025Article
- Progressive Changes Between Thalamic Nuclei and Cortical Networks Across Stimulus-Response Learning.Human brain mapping · 2025Article
- Investigating the neural correlates of the left thalamus in women with fibromyalgia: A Granger causality and voxel-based morphometry approach.SAGE open medicine · 2025Article
- Systematic cross-sectional age-associations in global fMRI signal topography.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Thalamic functional dysconnectivity in patients with left-hemisphere chronic capsular and pontine stroke.Frontiers in neuroscience · 2024Article
- Modeling the role of the thalamus in resting-state functional connectivity: Nature or structure.PLoS computational biology · 2023Article
- Differences in electroencephalography oscillations between normal aging and mild cognitive impairment during semantic memory retrieval.The European journal of neuroscience · 2023Article
- The Mediating Role of Vision in the Relationship between Proprioception and Postural Control in Older Adults, as Compared to Teenagers and Younger and Middle-Aged Adults.Healthcare (Basel, Switzerland) · 2022Article
- Thalamo-cortical inter-subject functional correlation during movie watching across the adult lifespan.Frontiers in neuroscience · 2022Article
- Reconfiguration of Directed Functional Connectivity Among Neurocognitive Networks with Aging: Considering the Role of Thalamo-Cortical Interactions.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Thalamic Structural Connectivity Abnormalities in Minimal Hepatic Encephalopathy.Frontiers in neuroanatomy · 2021Article
- Cytoplasmic mislocalization and mitochondrial colocalization of TDP-43 are common features between normal aged and young mice.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Regional Myo-Inositol, Creatine, and Choline Levels Are Higher at Older Age and Scale Negatively with Visuospatial Working Memory: A Cross-Sectional Proton MR Spectroscopy Study at 7 Tesla on Normal Cognitive Ageing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory.Frontiers in aging neuroscience · 2020Article
- Thalamic functional connectivity and its association with behavioral performance in older age.Brain and behavior · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Introduction: Despite the thalamus' dense connectivity with both cortical and subcortical structures, few studies have specifically investigated how thalamic connectivity changes with age and how such changes are associated with behavior. This study investigated the effect of age on thalamo-cortical and thalamo-hippocampal functional connectivity (FC) and the association between thalamic FC and visual-spatial memory and reaction time (RT) performance in older adults. Methods: Resting-state functional magnetic resonance images were obtained from younger ( Results: Older adults exhibited a loss of specificity in the FC between sensory thalamic subregions and corresponding sensory cortex. Greater thalamo-motor FC in older adults was associated with faster RTs. Furthermore, older adults exhibited greater thalamo-hippocampal FC compared to younger adults, which was greatest for those with the poorest visual-spatial memory performance. Conclusion: Although older adults exhibited poorer visual-spatial memory and slower reaction times compared to younger adults, "good" and "poorer" older performers exhibited different patterns of thalamo-cortical and thalamo-hippocampal FC. These results highlight the potential role of thalamic connectivity in supporting reaction times and memory in aging. Furthermore, these results highlight the importance of including the thalamus in studies of aging to fully understand how brain changes with age may be associated with behavior.
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