Evidence map›Paper›PMID 29670704›Full record

ArticleACS medicinal chemistry letters2018

Optimization of a β-Lactam Scaffold for Antibacterial Activity via the Inhibition of Bacterial Type I Signal Peptidase.

Chien-Hung Yeh, Shawn I Walsh, Arryn Craney, M Greg Tabor, Ana-Florina Voica, Ramkrishna Adhikary, Sydney E Morris, Floyd E Romesberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. A positive positive to negative.Nature chemistry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Chien-Hung YehDepartment of Chemistry, The Scripps Research Institute, La Jolla California 92037 United States.
Shawn I WalshDepartment of Chemistry, The Scripps Research Institute, La Jolla California 92037 United States.
Arryn CraneyDepartment of Chemistry, The Scripps Research Institute, La Jolla California 92037 United States.
M Greg TaborDepartment of Chemistry, The Scripps Research Institute, La Jolla California 92037 United States.
Ana-Florina VoicaDepartment of Chemistry, The Scripps Research Institute, La Jolla California 92037 United States.
Ramkrishna AdhikaryDepartment of Chemistry, The Scripps Research Institute, La Jolla California 92037 United States.
Sydney E MorrisDepartment of Chemistry, The Scripps Research Institute, La Jolla California 92037 United States.
Floyd E RomesbergDepartment of Chemistry, The Scripps Research Institute, La Jolla California 92037 United States.
Scripps Research Institute · US

Funding

Beyond translocation - non-canonical activities of bacterial signal peptidaseR21AI109809 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ROMESBERG, FLOYD E. · 2015 to 2016
$499k
NIAID NIH HHS R21 AI109809
6 · The paper itself

Abstract

β-Lactam antibiotics, one of the most important class of human therapeutics, act via the inhibition of penicillin-binding proteins (PBPs). The unparalleled success in their development has inspired efforts to develop them as inhibitors of other targets. Bacterial type I signal peptidase is evolutionarily related to the PBPs, but the stereochemistry of its substrates and its catalytic mechanism suggest that β-lactams with the 5

Identifiers

PMID29670704
PMCPMC5900324
OpenAlexW2792444106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.