Evidence map›Paper›PMID 29670657›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2018

Effects of Qi-Fang-Xi-Bi-Granules on Cartilage Morphology and C/ebp

Xinxin Wang, Peng Shen, Dezhi Tang, Hao Xu, Hongfu Qiu, Tao Wu, Xiang Gao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xinxin WangDepartment of Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.ORCID 0000-0003-1967-0509
Peng ShenDepartment of Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Dezhi TangSpine Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.ORCID 0000-0002-6528-0731
Hao XuSpine Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Hongfu QiuDepartment of Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Tao WuDepartment of Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Xiang GaoDepartment of Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.ORCID 0000-0003-1993-763X
Fudan University · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effects of Qi-Fang-Xi-Bi-Granules (QFXBGs) on cartilage morphology and methylation of C/ebp

methodsKnee osteoarthritis (KOA) modeling was performed in rats in accordance with Hulth's method, and control group received sham operation. Eight weeks after KOA modeling, the rats in the KOA modeling group were further divided into 6 groups. Each group was given the appropriate drug. After 8 weeks, half of the rats were used for Micro-CT scan, HE staining, ABH/OG staining, immunohistochemistry, and TUNNEL staining of the knee joint tissue, and the other half were used to examine C/ebp

resultsThe three dose groups of QFXBGs all showed lower degrees of surface fissures and flaking, thicker cartilage layer, and restored chondrocyte and subchondral bone morphology, compared with the KOA model group. C/ebp

conclusionsQFXBGs may alleviate articular cartilage degeneration through promoting C/ebp

Identifiers

PMID29670657
PMCPMC5833195
OpenAlexW2785752629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.