Evidence map›Paper›PMID 29670629›Full record

ArticleFrontiers in immunology2018

Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters.

David A Rhodes, Hung-Chang Chen, James C Williamson, Alfred Hill, Jack Yuan, Sam Smith, Harriet Rhodes, John Trowsdale, Paul J Lehner, Thomas Herrmann and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. BTN3A: A Promising Immune Checkpoint for Cancer Prognosis and Treatment.International journal of molecular sciences · 2022
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Suppressive activity of Vδ2Cancer immunology, immunotherapy : CII · 2020
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

David A RhodesDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Hung-Chang ChenDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
James C WilliamsonCambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Alfred HillDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Jack YuanDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Sam SmithDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Harriet RhodesDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
John TrowsdaleDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Paul J LehnerCambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
Thomas HerrmannInstitut für Virologie und Immunbiologie, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
Matthias EberlDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
University of Cambridge · GBCardiff University · GBUniversity of Würzburg · DE

Funding

Department of Health II-LA-0712-20006Medical Research Council MC_PC_13060Medical Research Council MR/M020290/1Medical Research Council MR/N023145/1Wellcome Trust 210688/Z/18/Z
6 · The paper itself

Abstract

Activation of human Vγ9/Vδ2 T cells by "phosphoantigens" (pAg), the microbial metabolite (

Indexed as

Antigen PresentationAntigens, CDATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2ButyrophilinsDiphosphatesHeLa CellsHLA AntigensHumansInterferon-gammaLymphocyte ActivationNeoplasm ProteinsProtein StabilityReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocytes4-hydroxy-3-methylbut-2-enyl pyrophosphateABCA1 protein, humanABCG1 protein, humanABCG2 protein, humanAntigens, CDATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2BTN3A1 protein, humanButyrophilinsDiphosphatesHLA AntigensInterferon-gammaNeoplasm ProteinsReceptors, Antigen, T-Cell, gamma-deltaT-cell receptor Vdelta2, humanT-cell receptor Vgamma9, humanABCG2butyrophilinsmevalonate pathwayNRF2phosphoantigensT cells

Identifiers

PMID29670629
PMCPMC5893821
OpenAlexW2795856350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.