Evidence map›Paper›PMID 29670609›Full record

ArticleFrontiers in immunology2018

Enhanced Replication of Virulent Newcastle Disease Virus in Chicken Macrophages Is due to Polarized Activation of Cells by Inhibition of TLR7.

Pingze Zhang, Zhuang Ding, Xinxin Liu, Yanyu Chen, Junjiao Li, Zhi Tao, Yidong Fei, Cong Xue, Jing Qian, Xueli Wang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Pingze ZhangDepartment of Veterinary Preventive Medicine, College of Veterinary Medicine, Jilin University, Changchun, China.
Zhuang DingDepartment of Veterinary Preventive Medicine, College of Veterinary Medicine, Jilin University, Changchun, China.
Xinxin LiuCollege of Food Science and Engineering, Jilin University, Changchun, China.
Yanyu ChenDepartment of Veterinary Preventive Medicine, College of Veterinary Medicine, Jilin University, Changchun, China.
Junjiao LiDepartment of Veterinary Preventive Medicine, College of Veterinary Medicine, Jilin University, Changchun, China.
Zhi TaoDepartment of Veterinary Preventive Medicine, College of Veterinary Medicine, Jilin University, Changchun, China.
Yidong FeiDepartment of Veterinary Preventive Medicine, College of Veterinary Medicine, Jilin University, Changchun, China.
Cong XueDepartment of Veterinary Preventive Medicine, College of Veterinary Medicine, Jilin University, Changchun, China.
Jing QianDepartment of Veterinary Preventive Medicine, College of Veterinary Medicine, Jilin University, Changchun, China.
Xueli WangCollege of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao, China.
Qingmei LiLaboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, China.
Tobias StoegerComprehensive Pneumology Center, Institute of Lung Biology and Disease (iLBD), Helmholtz Zentrum Muenchen, Munich, Germany.
Jianjun ChenCAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Hubei, China.
Yuhai BiCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Renfu YinDepartment of Veterinary Preventive Medicine, College of Veterinary Medicine, Jilin University, Changchun, China.
Jilin University · CNChinese Academy of Sciences · CNHelmholtz Zentrum München · DEHenan Academy of Agricultural Sciences · CNInner Mongolia University for Nationalities · CNWuhan Institute of Virology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Newcastle disease (ND), caused by infections with virulent strains of Newcastle disease virus (NDV), is one of the most important infectious disease affecting wild, peridomestic, and domestic birds worldwide. Vaccines constructed from live, low-virulence (lentogenic) viruses are the most accepted prevention and control strategies for combating ND in poultry across the globe. Avian macrophages are one of the first cell lines of defense against microbial infection, responding to signals in the microenvironment. Although macrophages are considered to be one of the main target cells for NDV infection

Indexed as

VirulenceAnimalsAvian ProteinsBone Marrow CellsCell DifferentiationCell LineChickensCytokinesMacrophage ActivationMacrophagesNewcastle DiseaseNewcastle disease virusTh1 CellsTh2 CellsToll-Like Receptor 7Virus ReplicationAvian ProteinsCytokinesToll-Like Receptor 7chicken macrophagesimmune responsemacrophage polarized activationnewcastle disease virustoll-like receptor 7virus growth

Identifiers

PMID29670609
PMCPMC5893744
OpenAlexW2795897164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.