Evidence map›Paper›PMID 29670586›Full record

ArticleFrontiers in microbiology2018

A New Age-Structured Multiscale Model of the Hepatitis C Virus Life-Cycle During Infection and Therapy With Direct-Acting Antiviral Agents.

Barbara de M Quintela, Jessica M Conway, James M Hyman, Jeremie Guedj, Rodrigo W Dos Santos, Marcelo Lobosco, Alan S Perelson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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  13. Advanced Hepatitis C Virus Replication PDE Models within a Realistic Intracellular Geometric Environment.International journal of environmental research and public health · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Barbara de M QuintelaFISIOCOMP Laboratory, PPGMC, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
Jessica M ConwayDepartment of Mathematics and Center for Infectious Disease Dynamics, The Pennsylvania State University, State College, PA, United States.
James M HymanMathematics Department, Tulane University, New Orleans, LA, United States.
Jeremie GuedjIAME, UMR 1137, Institut National de la Santé et de la Recherche Médicale, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
Rodrigo W Dos SantosFISIOCOMP Laboratory, PPGMC, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
Marcelo LoboscoFISIOCOMP Laboratory, PPGMC, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
Alan S PerelsonTheoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, United States.
Universidade Federal de Juiz de Fora · BRInserm · FRLos Alamos National Laboratory · USPennsylvania State University · USTulane University · US

Funding

Spatial Models of Intrahepatic Hepatitis C Virus Propagation in HumansR01AI116868 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI ASHWIN BALAGOPAL, Ruy M Ribeiro · 2016 to 2026
$8.5M
Collaborative Integration of HCV Molecular Virology and Mathematical ModelingR01AI078881 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PERELSON, ALAN S, UPRICHARD, SUSAN L. · 2011 to 2025
$7.5M
Modeling Viral and T Lymphocyte DynamicsR01OD011095 · OD · TRIAD NATIONAL SECURITY, LLC · PI PERELSON, ALAN S · 2012 to 2024
$5.0M
Immune System Modeling/HIVR01AI028433 · NIAID · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI PERELSON, ALAN S · 1990 to 2021
$3.7M
NIAID NIH HHS R01 AI028433NIAID NIH HHS R01 AI078881NIAID NIH HHS R01 AI116868NIH HHS R01 OD011095
6 · The paper itself

Abstract

The dynamics of hepatitis C virus (HCV) RNA during translation and replication within infected cells were added to a previous age-structured multiscale mathematical model of HCV infection and treatment. The model allows the study of the dynamics of HCV RNA inside infected cells as well as the release of virus from infected cells and the dynamics of subsequent new cell infections. The model was used to fit

Indexed as

computational biologyDAAsdifferential equationsHCVRNA

Identifiers

PMID29670586
PMCPMC5893852
OpenAlexW2796064518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.