ArticleFrontiers in endocrinology2018
Anatomical Variation of Age-Related Changes in Vertebral Bone Marrow Composition Using Chemical Shift Encoding-Based Water-Fat Magnetic Resonance Imaging.
Article in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 81 citations in OpenAlex.
- Effect of artificial gravity on calcaneal bone marrow adipose tissue and mineral content in female and male participants in 60 days of bed rest.Experimental physiology · 2026Trial
- Changes in Bone Marrow Fat upon Dietary-Induced Weight Loss.Nutrients · 2020Trial
- Comparative analysis of novel vertebral bone quality score variants for predicting cage subsidence following single-level anterior cervical discectomy and fusion: a retrospective cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Regional variation in vertebral bone marrow adiposity: a population-based atlas of age- and sex-specific patterns.Skeletal radiology · 2026Article
- [Metabolism and bone marrow : Imaging of physiological and pathological processes].Radiologie (Heidelberg, Germany) · 2026Review
- Review
- On-Scanner Correction of Gradient Nonlinearity Bias for Accurate Assessment of Diffusion Heterogeneity Across Bone Sites in Myelofibrosis Patients.Magnetic resonance in medicine · 2026Article
- Multiple vertebrae improves precision in image-based bone marrow absorbed dose estimation in [EJNMMI physics · 2026Article
- A three-material model for dual-layer detector spectral computed tomography measurements of marrow adipose tissue and bone mineral density.JBMR plus · 2025Article
- A novel deep learning method for large-scale analysis of bone marrow adiposity using UK Biobank Dixon MRI data.Computational and structural biotechnology journal · 2024Article
- Accuracy, repeatability, and reproducibility of water-fat magnetic resonance imaging in a phantom and healthy volunteer.Physics and imaging in radiation oncology · 2024Article
- Nutrition and Bone Marrow Adiposity in Relation to Bone Health.Physiological research · 2024Review
- Automated shape-independent assessment of the spatial distribution of proton density fat fraction in vertebral bone marrow.Zeitschrift fur medizinische Physik · 2024Article
- Longitudinal MR-based proton-density fat fraction (PDFF) and T2* for the assessment of associations between bone marrow changes and myelotoxic chemotherapy.European radiology · 2024Article
- Directional microwave ablation in spine: experimental assessment of computational modeling.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024Article
- 3T-MRI-based age, sex and site-specific markers of musculoskeletal health in healthy children and young adults.Endocrine connections · 2022Article
- The Implications of Bone Marrow Adipose Tissue on Inflammaging.Frontiers in endocrinology · 2022Review
- PiT2 deficiency prevents increase of bone marrow adipose tissue during skeletal maturation but not in OVX-induced osteoporosis.Frontiers in endocrinology · 2022Article
- Finite Element Analysis of Osteoporotic and Osteoblastic Vertebrae and Its Association With the Proton Density Fat Fraction From Chemical Shift Encoding-Based Water-Fat MRI - A Preliminary Study.Frontiers in endocrinology · 2022Article
- Changes in Vertebral Marrow Fat Fraction Using 3D Fat Analysis & Calculation Technique Imaging Sequence in Aromatase Inhibitor-Treated Breast Cancer Women.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Assessment of vertebral bone marrow composition has been proposed as imaging biomarker for osteoporosis, hematopoietic, and metabolic disorders. We investigated the anatomical variation of age-related changes of vertebral proton density fat fraction (PDFF) using chemical shift encoding-based water-fat magnetic resonance imaging (MRI). 156 healthy subjects were recruited (age range 20-29 years: 12/30 males/females; 30-39: 15/9; 40-49: 4/14; 50-59: 9/27; 60-69: 5/19; 70-79: 4/8). An eight-echo 3D spoiled gradient-echo sequence at 3T MRI was used for chemical shift-encoding based water-fat separation at the lumbar spine. Vertebral bodies of L1-L4 were manually segmented to extract PDFF values at each vertebral level. PDFF averaged over L1-L4 was significantly (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.