ArticleFrontiers in neurology2018
Gait Asymmetry in People With Parkinson's Disease Is Linked to Reduced Integrity of Callosal Sensorimotor Regions.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Gait asymmetry in Parkinson's disease - a systematic review and meta-analysis (AsymmGait-Parkinson study).Scientific reports · 2026Pooled it
- Using explainable AI to identify disease-relevant and deep brain stimulation treatment-sensitive gait features in Parkinson's disease.Journal of neuroengineering and rehabilitation · 2026Article
- Cross-Modal Synergy Representation of EMG and Joint Angular Acceleration During Gait in Parkinson's Disease Using NMF and Multimodal Matrix Factorization.Sensors (Basel, Switzerland) · 2026Article
- Weight-bearing symmetry changes after asymmetric surface stiffness walking.Journal of neurophysiology · 2026Article
- Deep Convolutional Neural Network-Based Detection of Gait Abnormalities in Parkinson's Disease Using Fewer Plantar Sensors in a Smart Insole.Biosensors · 2026Article
- Inter-segmental coordination patterns in Parkinson's disease are particularly disturbed during preferred walking speed: a data-driven network approach.Journal of neuroengineering and rehabilitation · 2025Article
- The potential of distributed diagnostics for the early detection of Parkinson's disease.Journal of Parkinson's disease · 2025Review
- Differential gait features across Parkinson's disease clinical subtypes.Clinical biomechanics (Bristol, Avon) · 2025Article
- Rhythmic auditory cues improve gait asymmetry during unobstructed walking in people with Parkinson's disease but have no effect on obstacle avoidance - AsymmGait-Parkinson study.Frontiers in aging neuroscience · 2025Article
- Classification of Parkinson's disease severity using gait stance signals in a spatiotemporal deep learning classifier.Medical & biological engineering & computing · 2024Article
- Kinematic network of joint motion provides insight on gait coordination: An observational study on Parkinson's disease.Heliyon · 2024Article
- Stride width and postural stability in frontal gait disorders and Parkinson's disease.Journal of neurology · 2024Article
- Gait asymmetry and symptom laterality in Parkinson's disease: two of a kind?Journal of neurology · 2024Article
- Gait Analysis with Wearable Sensors in Isolated REM Sleep Behavior Disorder Associated with Phenoconversion: An Explorative Study.Journal of Parkinson's disease · 2024Article
- A Comparative Analysis of Symmetry Indices for Spatiotemporal Gait Features in Early Parkinson's Disease.Neurology international · 2023Article
- (A)symmetry during gait initiation in people with Parkinson's disease: A motor and cortical activity exploratory study.Frontiers in aging neuroscience · 2023Article
- Isolating the speed factor is crucial in gait analysis for Parkinson's disease.Frontiers in neuroscience · 2023Article
- The effect of action observation training on gait and balance of patients with neurological and musculoskeletal disorders: A systematic review.The British journal of occupational therapy · 2022Review
- Distinct gait dimensions are modulated by physical activity in Parkinson's disease patients.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- A Study on Lower Limb Asymmetries in Parkinson's Disease during Gait Assessed through Kinematic-Derived Parameters.Bioengineering (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIndividuals with Parkinson's disease (PD) often manifest significant temporal and spatial asymmetries of the lower extremities during gait, which significantly contribute to mobility impairments. While the neural mechanisms underlying mobility asymmetries within this population remain poorly understood, recent evidence points to altered microstructural integrity of white matter fiber tracts within the corpus callosum as potentially playing a substantial role.
objectivesThe purpose of this study was to quantify spatial and temporal gait asymmetries as well as transcallosal microstructural integrity of white matter fiber tracts connecting the primary and secondary sensorimotor cortices in people with PD and age-matched control participants.
methodsSpatial and temporal gait asymmetry in the levodopa off state was assessed using an instrumented walkway. On the next day, diffusion-weighted images were collected to assess white matter microstructural integrity in transcallosal fibers connecting the homologous sensorimotor cortical regions.
resultsPeople with PD exhibited significantly more temporal and spatial gait asymmetry than healthy control subjects. Furthermore, people with PD had significantly reduced white matter microstructural integrity of transcallosal fibers connecting homologous regions of the pre-supplementary motor and supplementary motor areas (SMAs), but not the primary motor or somatosensory cortices. Finally, reduced transcallosal fiber tract integrity of the pre-SMA and S1 was associated with greater step length asymmetry in people with PD.
conclusionPeople with PD showed increased step length asymmetries and decreased microstructural integrity of callosal white matter tracts connecting the higher-order sensorimotor cortices (pre-SMA and SMA). The strong association between gait asymmetries and corpus collosum integrity, supports the hypothesis that reduced transcallosal structural connectivity is a significant mechanism underlying gait asymmetries in people with PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.