ArticleFrontiers in neurology2018
The Dynamics of Concussion: Mapping Pathophysiology, Persistence, and Recovery With Causal-Loop Diagramming.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05425303 (Development of a System Dynamics Model for the Prediction of Acute Non-contact Lower Extremity Injuries in Team Sports), which is not on this map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of a System Dynamics Model for the Prediction of Acute Non-contact Lower Extremity Injuries in Team Sports
Who cites it
41 citing papers in PubMed.
- Responsivity of Concussion Symptom Domains to a Mind-Body Intervention for Young Adults With a Recent Concussion and Anxiety: A Pilot RCT.The Journal of head trauma rehabilitationTrial
- Preliminary Evaluation of the Circle Sequencing Task (CST) as a Cognitive-Motor Tool for Concussion Assessment.Sports (Basel, Switzerland) · 2026Article
- Diagrams-to-Dynamics (D2D): Exploring causal loop diagram leverage points under uncertainty.BMC medicine · 2026Article
- The Young Adult Sleep model: an evolving causal loop diagram of mental health dynamics.BMC medicine · 2026Article
- [Progress on the application of system dynamics model in the field of health management].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025Review
- If things were simple, word would have gotten around. Can complexity science help us improve pediatric research?Pediatric research · 2025Review
- The Impact of Background Music on Flow, Work Engagement and Task Performance: A Randomized Controlled Study.Behavioral sciences (Basel, Switzerland) · 2025Article
- How Are TBI Symptoms Interconnected? A Network Analysis Approach.Brain and behavior · 2025Article
- Advances and Challenges in Traumatic Brain Injury from a Forensic Perspective.Current neuropharmacology · 2025Review
- Longitudinal changes following the introduction of socially assistive robots in nursing homes: a qualitative study with ICF framework and causal loop diagramming.BMC geriatrics · 2024Article
- Postconcussive symptom severity, risk factors for prolonged recovery, and mental health history: Pathways of influence in a diverse pediatric sample.Annals of the Child Neurology Society · 2024Article
- An Objective Assessment of Neuromotor Control Using a Smartphone App After Repeated Subconcussive Blast Exposure.Sensors (Basel, Switzerland) · 2024Article
- Persistent MRI Findings Unique to Blast and Repetitive Mild TBI: Analysis of the CENC/LIMBIC Cohort Injury Characteristics.Military medicine · 2024Observational
- Mapping complex public health problems with causal loop diagrams.International journal of epidemiology · 2024Article
- CARE4Kids Study: Endophenotypes of Persistent Post-Concussive Symptoms in Adolescents: Study Rationale and Protocol.Journal of neurotrauma · 2024Article
- Using network analysis to identify leverage points based on causal loop diagrams leads to false inference.Scientific reports · 2023Article
- Astrocytes in human central nervous system diseases: a frontier for new therapies.Signal transduction and targeted therapy · 2023Review
- Applying systems thinking to unravel the mechanisms underlying orthostatic hypotension related fall risk.GeroScience · 2023Article
- Factors related to adverse long-term outcomes after mild traumatic brain injury in children: a scoping review.Archives of disease in childhood · 2023Article
- Inflammatory cytokines associated with mild traumatic brain injury and clinical outcomes: a systematic review and meta-analysis.Frontiers in neurology · 2023Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Despite increasing public awareness and a growing body of literature on the subject of concussion, or mild traumatic brain injury, an urgent need still exists for reliable diagnostic measures, clinical care guidelines, and effective treatments for the condition. Complexity and heterogeneity complicate research efforts and indicate the need for innovative approaches to synthesize current knowledge in order to improve clinical outcomes. Methods from the interdisciplinary field of systems science, including models of complex systems, have been increasingly applied to biomedical applications and show promise for generating insight for traumatic brain injury. The current study uses causal-loop diagramming to visualize relationships between factors influencing the pathophysiology and recovery trajectories of concussive injury, including persistence of symptoms and deficits. The primary output is a series of preliminary systems maps detailing feedback loops, intrinsic dynamics, exogenous drivers, and hubs across several scales, from micro-level cellular processes to social influences. Key system features, such as the role of specific restorative feedback processes and cross-scale connections, are examined and discussed in the context of recovery trajectories. This systems approach integrates research findings across disciplines and allows components to be considered in relation to larger system influences, which enables the identification of research gaps, supports classification efforts, and provides a framework for interdisciplinary collaboration and communication-all strides that would benefit diagnosis, prognosis, and treatment in the clinic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.