Evidence map›Paper›PMID 29670509›Full record

ArticleFrontiers in molecular neuroscience2018

Altered Gene-Regulatory Function of KDM5C by a Novel Mutation Associated With Autism and Intellectual Disability.

Christina N Vallianatos, Clara Farrehi, Michael J Friez, Margit Burmeister, Catherine E Keegan, Shigeki Iwase

Abstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

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  7. Emerging role ofFrontiers in molecular neuroscience · 2026
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  16. Asynchronous microexon splicing ofbioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christina N VallianatosDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, United States.
Clara FarrehiDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, United States.
Michael J FriezDiagnostic Laboratory, Greenwood Genetic Center, Greenwood, SC, United States.
Margit BurmeisterDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, United States.
Catherine E KeeganDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, United States.
Shigeki IwaseDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, United States.

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
Career Training in Reproductive BiologyT32HD079342 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Suzanne M MOENTER · 2014 to 2026
$2.3M
Neutralizing epigenomes in neurodevelopment disordersR01NS089896 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI IWASE, SHIGEKI · 2015 to 2019
$2.1M
NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR002240NICHD NIH HHS T32 HD079342NIGMS NIH HHS T32 GM007544NINDS NIH HHS R01 NS089896
6 · The paper itself

Abstract

Intellectual disability (ID) affects up to 2% of the population world-wide and often coincides with other neurological conditions such as autism spectrum disorders. Mutations in

Indexed as

autism spectrum disorderschromatinhistone demethylaseKDM5C/SMCX/JARID1Cmutation analysisneuroepigeneticsX-linked intellectual disability

Identifiers

PMID29670509
PMCPMC5893713

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.