Evidence map›Paper›PMID 29670506›Full record

ArticleFrontiers in neuroscience2018

Dexterous Control of Seven Functional Hand Movements Using Cortically-Controlled Transcutaneous Muscle Stimulation in a Person With Tetraplegia.

Samuel C Colachis, Marcie A Bockbrader, Mingming Zhang, David A Friedenberg, Nicholas V Annetta, Michael A Schwemmer, Nicholas D Skomrock, Walter J Mysiw, Ali R Rezai, Herbert S Bresler and 1 more

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01997125 nacompletednot on this map

Reanimation in Tetraplegia: Restoring Cortical Control of Functional Movement in Humans With Quadriplegia

TypeinterventionalSponsorMarcia BockbraderRan2013 to 2019Enrolled1ConditionsSpinal Cord Injury (Quadraplegia)ArmsNeural Bridge System
NCT04075812 nacompletednot on this map

High Definition Neuromuscular Stimulation in Tetraplegia

TypeinterventionalSponsorOhio State UniversityRan2013 to 2019Enrolled2ConditionsSpinal Cord Injury at C4-C6 LevelArmsNeuromuscular Stimulator
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Brain-computer interface: an update for the clinicians.Frontiers in human neuroscience · 2026
    Review
  5. Article
  6. [Motion analysis in Orthopaedic technology research].Unfallchirurgie (Heidelberg, Germany) · 2025
    Review
  7. Article
  8. An Investigation of Manifold-Based Direct Control for a Brain-to-Body Neural Bypass.IEEE open journal of engineering in medicine and biology · 2024
    Article
  9. Review
  10. Review
  11. When neuro-robots go wrong: A review.Frontiers in neurorobotics · 2023
    Review
  12. Neural Decoding for Intracortical Brain-Computer Interfaces.Cyborg and bionic systems (Washington, D.C.) · 2023
    Review
  13. Review
  14. The role of electrical stimulation for rehabilitation and regeneration after spinal cord injury.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2022
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Samuel C ColachisMedical Devices and Neuromodulation Group, Battelle Memorial Institute, Columbus, OH, United States.
Marcie A BockbraderNeurological Institute, The Ohio State University, Columbus, OH, United States.
Mingming ZhangMedical Devices and Neuromodulation Group, Battelle Memorial Institute, Columbus, OH, United States.
David A FriedenbergAdvanced Analytics Group, Battelle Memorial Institute, Columbus, OH, United States.
Nicholas V AnnettaMedical Devices and Neuromodulation Group, Battelle Memorial Institute, Columbus, OH, United States.
Michael A SchwemmerAdvanced Analytics Group, Battelle Memorial Institute, Columbus, OH, United States.
Nicholas D SkomrockAdvanced Analytics Group, Battelle Memorial Institute, Columbus, OH, United States.
Walter J MysiwNeurological Institute, The Ohio State University, Columbus, OH, United States.
Ali R RezaiNeurological Institute, The Ohio State University, Columbus, OH, United States.
Herbert S BreslerMedical Devices and Neuromodulation Group, Battelle Memorial Institute, Columbus, OH, United States.
Gaurav SharmaMedical Devices and Neuromodulation Group, Battelle Memorial Institute, Columbus, OH, United States.
Battelle · USThe Neurological Institute · USThe Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individuals with tetraplegia identify restoration of hand function as a critical, unmet need to regain their independence and improve quality of life. Brain-Computer Interface (BCI)-controlled Functional Electrical Stimulation (FES) technology addresses this need by reconnecting the brain with paralyzed limbs to restore function. In this study, we quantified performance of an intuitive, cortically-controlled, transcutaneous FES system on standardized object manipulation tasks from the Grasp and Release Test (GRT). We found that a tetraplegic individual could use the system to control up to seven functional hand movements, each with >95% individual accuracy. He was able to select one movement from the possible seven movements available to him and use it to appropriately manipulate all GRT objects in real-time using naturalistic grasps. With the use of the system, the participant not only improved his GRT performance over his baseline, demonstrating an increase in number of transfers for all objects except the

Indexed as

brain-computer interfacefunctional electrical stimulationfunctional hand graspingneuro-orthoticsspinal cord injury

Identifiers

PMID29670506
PMCPMC5893794
OpenAlexW2795897352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.