ArticleMateria socio-medica2018
Exercise-Associated Muscle Cramp-Doubts About the Cause.
Article in Materia socio-medica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Risk Factors for Exercise-Associated Muscle Cramps: A Systematic Review With Meta-Analysis.Muscle & nerve · 2026Pooled it
- Surface mechanical properties as a potential upstream contributor to exercise-associated muscle cramp susceptibility: a hypothesis linking athlete-surface interaction, neuromuscular fatigue, and altered neuromuscular control.Frontiers in sports and active living · 2026Article
- Low-Osmolality Carbohydrate-Electrolyte Solution Ingestion Avoid Fluid Loss and Oxidative Stress After Exhaustive Endurance Exercise.Antioxidants (Basel, Switzerland) · 2020Article
- Muscle Cramping During Exercise: Causes, Solutions, and Questions Remaining.Sports medicine (Auckland, N.Z.) · 2019Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionExercise-associated muscle cramp (EAMC) is one of the most common conditions that occur during or immediately after the exercise, with questionable etiology.
aimAim of article was to present doubts about the cause of EAMC, whether it is primarily a neurological condition or it is water and salt imbalance.
resultsStrongest evidence supports the neuromuscular aetiology with the focus on the muscle fatigue. Muscle overload and fatigue affects the balance between the excitatory drive from muscle spindles and the inhibitory drive from the Golgi tendon organs (GTO). This results in a localized muscle cramp. Since the dehydration and electrolyte depletion are systemic abnormalities, it is not clear how these changes would result in local symptoms such as cramping of the working muscle groups.
conclusion"Triad" of causes might be behind the etiology of EAMC, although the "altered neuromuscular control" theory with the "dehydration" theory is the most cogent descriptive model that explains the origin of EAMC. Treatment and prevention strategies for EAMC include: electrical cramp induction, kinesio taping and compression garments, massage therapy, electrolyte supplementation and hydration, corrective exercise, stretching, quinine, pickle juice, hyperventilation strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.