ArticleNeuropsychiatric disease and treatment2018
Inhibitory effect of the Kampo medicinal formula Yokukansan on acute stress-induced defecation in rats.
Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 11 citations in OpenAlex.
- Variability in Oxytocin Blood Levels in Rats: A Review and Experimental Insights.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Analgesic Effect of Combined Therapy with the Japanese Herbal Medicine "Medicines (Basel, Switzerland) · 2021Article
- Kampo Formulae for the Treatment of Neuropathic Pain ∼ Especially the Mechanism of Action ofFrontiers in molecular neuroscience · 2021Review
- Analgesic Efficacy of a Combination of Fentanyl and a Japanese Herbal Medicine "Medicines (Basel, Switzerland) · 2020Article
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9 authors at 1 institution in 1 country.
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Abstract
objectivesIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder with symptoms of abnormal defecation and abdominal discomfort. Psychological factors are well known to be involved in onset and exacerbation of IBS. A few studies have reported effectiveness of traditional herbal (Kampo) medicines in IBS treatment. Yokukansan (YKS) has been shown to have anti-stress and anxiolytic effects. We investigated the effect of YKS on defecation induced by stress and involvement of oxytocin (OT), a peptide hormone produced by the hypothalamus, in order to elucidate the mechanism of YKS action. METHODS AND
resultsMale Wistar rats were divided into four groups; control, YKS (300 mg/kg PO)-treated non-stress (YKS), acute stress (Stress), and YKS (300 mg/kg PO)-treated acute stress (Stress+YKS) groups. Rats in the Stress and Stress+YKS groups were exposed to a 15-min psychological stress procedure involving novel environmental stress. Levels of plasma OT in the YKS group were significantly higher compared with those in the Control group (
conclusionThese results suggested that YKS influences stress-induced defecation and that increased OT secretion may be a mechanism underlying this phenomenon.
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