Evidence map›Paper›PMID 29670328›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2018

Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study.

Marguerite B McDonald, Hosam Sheha, Sean Tighe, Susan B Janik, Frank W Bowden, Amit R Chokshi, Michael A Singer, Seema Nanda, Mujtaba A Qazi, Damon Dierker and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04553432 (Dry Eye OmniLenz Application of Omnigen Research Study), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04553432 phase4completednot on this mapstarted 2020, after this paper: background citation

Dry Eye OmniLenz Application of Omnigen Research Study

TypeinterventionalSponsorAston UniversityRan2020 to 2023Enrolled79ConditionsDry EyeArmsAmniotic membrane Omnigen[TM], Bandage soft Contact Lens OmniLenz[R]
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 2 countries.

Marguerite B McDonaldOphthalmic Consultants of Long Island, Lynbrook, NY, USA.
Hosam ShehaOcular Surface Center and TissueTech, Inc., Miami, FL, USA.
Sean TigheOcular Surface Center and TissueTech, Inc., Miami, FL, USA.
Susan B JanikSolinsky Eye Care, Kensington, CT, USA.
Frank W BowdenBowden Eye & Associates, Jacksonville, FL, USA.
Amit R ChokshiFlorida Eye Specialists, Jacksonville, FL, USA.
Michael A SingerMedical Center Ophthalmology Associates, San Antonio, TX, USA.
Seema NandaTX Eye Institute, Houston, TX, USA.
Mujtaba A QaziPepose Vision Institute, Chesterfield, MO, USA.
Damon DierkerEye Surgeons of Indiana, Indianapolis, IN, USA.
Adam T ShupeRoyo Eye Care, Marysville, CA, USA.
Brittany J McMurrenGordon and Weiss Vision Institute, San Diego, CA, USA.
Eye Care Associates · USEye Surgeons of Indiana · USFlorida Digestive Health Specialists · USFlorida International University · USGordon Schanzlin New Vision Institute · USHofstra University · USHouston Eye Associates · USMedical Center Ophthalmology Associates · USOcular Surface Center · USOphthalmic Consultants of Long Island · USPepose Vision Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the efficacy of cryopreserved amniotic membrane (CAM) in reducing signs and symptoms of dry eye disease (DED) in a large patient population.

methodsA retrospective chart review at 10 clinical sites was done of patients with refractory DED who received CAM and completed at least 3 months of follow-up. Data collected were demographics; medical history including previous and current ocular treatment, diagnosis, clinical presentations, comorbidity, duration and frequency of treatment with CAM; and concomitant medications. The primary outcome was the change in dry eye workshop (DEWS) score after treatment.

resultsA total of 97 eyes of 84 patients exhibited severe dry eye despite maximal medical treatments including topical artificial tears, cyclosporine-A, serum, antibiotics, and steroids. Patients manifested with superficial punctate keratitis (86%), filamentary keratitis (13%), exposure keratitis (19%), neurotrophic keratitis (2%), and corneal epithelial defect (7%). After CAM treatment for 5.4±2.8 days, 74 (88%) patients demonstrated an improved ocular surface along with a notable reduction of the severity as the overall DEWS score was significantly reduced from 3.25±0.5 at baseline to 1.44±0.6 at 1 week, 1.45±0.6 at 1 month, and 1.47±0.6 at 3 months (

conclusionPlacement of CAM is promising to enhance the recovery of ocular surface health and reduce signs and symptoms in patients with moderate-to-severe DED.

Indexed as

amniotic membraneDEWSdry eyeocular surfaceseverity

Identifiers

PMID29670328
PMCPMC5898584
OpenAlexW2795808271

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.