ArticleNature2018
Structural basis of ligand binding modes at the neuropeptide Y Y
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Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69citing papers in PubMed
8.3field-weighted citation impact, top 1% of its field
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Who cites it
69 citing papers in PubMed, 142 citations in OpenAlex.
- Neuropeptide Y Receptor Binding Profiles of Endogenous Ligands in the Presence and Absence of Sodium: A Panoramic View.ACS pharmacology & translational science · 2026Article
- Fine-Tuning of the Neuropeptide Y1 G Protein-Coupled Receptor by the TryptophanJournal of the American Chemical Society · 2026Article
- Impaired Brain Incretin and Gut Hormone Expression in Human Alcohol-Related Brain Damage: Opportunities for Therapeutic Targeting.Biomolecules · 2026Article
- Selective Receptor Modulation by Truncated Neuropeptide Y (3-36) Dissociates Vasoconstriction from Neuroprotection in Experimental Glaucoma.Molecular neurobiology · 2025Article
- Ultra-large library screening with an evolutionary algorithm in Rosetta (REvoLd).Communications chemistry · 2025Article
- Leptin and G-protein coupled receptor (GPCR) signaling: Therapeutic potential in obesity.The Journal of biological chemistry · 2025Review
- Transient ligand contacts of the intrinsically disordered N-terminus of neuropeptide YNature communications · 2025Article
- Comparative Perspectives on Neuropeptide Function and Social Isolation.Biological psychiatry · 2025Review
- Telomere-related gene risk model predicts prognostic and immune microenvironment alterations in prostate cancer.Scientific reports · 2025Article
- A high-performance GRAB sensor reveals differences in the dynamics and molecular regulation between neuropeptide and neurotransmitter release.Nature communications · 2025Article
- Neuropeptide Y and Pain: Insights from Brain Research.ACS pharmacology & translational science · 2024Review
- Computational Methods for the Discovery and Optimization of TAAR1 and TAAR5 Ligands.International journal of molecular sciences · 2024Review
- Structural basis of neuropeptide Y signaling through YMedComm · 2024Article
- G Protein-Coupled Receptor-Ligand Pose and Functional Class Prediction.International journal of molecular sciences · 2024Article
- Article
- The role of neuropeptides in cutaneous wound healing: a focus on mechanisms and neuropeptide-derived treatments.Frontiers in bioengineering and biotechnology · 2024Review
- The bad and the good of trends in model building and refinement for sparse-data regions: pernicious forms of overfitting versus good new tools and predictions.Acta crystallographica. Section D, Structural biology · 2023Article
- Dynamics of the Second Extracellular Loop Control Transducer Coupling of Peptide-Activated GPCRs.International journal of molecular sciences · 2023Article
- Neuropeptide Y Peptide Family and Cancer: Antitumor Therapeutic Strategies.International journal of molecular sciences · 2023Review
- Improving the Modeling of Extracellular Ligand Binding Pockets in RosettaGPCR for Conformational Selection.International journal of molecular sciences · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 9 institutions in 4 countries.
Zhenlin YangChinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Shuo HanChinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Max KellerPharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany. max.keller@chemie.uni-regensburg.de.
Anette KaiserInstitute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany.
Brian J BenderDepartment of Pharmacology, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.
Mathias BosseInstitute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany.
Kerstin BurkertInstitute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany.
Lisa M KöglerInstitute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany.
David WiflingPharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany.
Guenther BernhardtPharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany.
Nicole PlankPharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany.
Timo LittmannPharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany.
Peter SchmidtInstitute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany.
Cuiying YiChinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Beibei LiChinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Sheng YeNational Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Rongguang ZhangNational Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Bo XuDepartment of Neuroscience, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Dan LarhammarDepartment of Neuroscience, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Raymond C StevensiHuman Institute, ShanghaiTech University, Shanghai, China.
Daniel HusterInstitute for Medical Physics and Biophysics, Leipzig University, Leipzig, Germany.
Jens MeilerDepartment of Pharmacology, Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.
Qiang ZhaoChinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Annette G Beck-SickingerInstitute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig, Germany. abeck-sickinger@uni-leipzig.de.
Armin BuschauerPharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany.
Beili WuChinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. beiliwu@simm.ac.cn.
Leipzig University · DEUniversity of Regensburg · DEChinese Academy of Sciences · CNInstitute of Biophysics · CNScience for Life Laboratory · SEShanghai Institute of Materia Medica · CNVanderbilt University · USShanghaiTech University · CNUniversity of Chinese Academy of Sciences · CN
Funding
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MDecrypting Variants of Uncertain Significance in Long-QT SyndromeR01HL122010 · NHLBI · VANDERBILT UNIVERSITY · PI GEORGE, ALFRED L., SANDERS, CHARLES R · 2014 to 2025
$15.5MTRAINING IN PHARMACOLOGICAL SCIENCEST32GM007628 · NIGMS · VANDERBILT UNIVERSITY · PI BARNETT, JOEY VICTOR, KAVALALI, EGE T · 1985 to 2022
$11.2MMembrane Protein Structure Elucidation from sparse NMR data (KAMP)R01GM080403 · NIGMS · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2007 to 2019
$3.0MSmall Molecule Probes to Investigate Structure and Function of Y ReceptorsR01DK097376 · NIDDK · VANDERBILT UNIVERSITY · PI MEILER, JENS, WEAVER, C DAVID · 2013 to 2015
$1.0MGPU-Accelerated Parallel Computer for Drug Discovery ApplicationsS10OD020154 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2015 to 2015
$225kNHLBI NIH HHS R01 HL122010NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK097376NIGMS NIH HHS R01 GM080403NIGMS NIH HHS T32 GM007628
Abstract
Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology
Indexed as
ArginineBinding SitesCrystallography, X-RayDihydropyridinesDiphenylacetic AcidsHumansInositol PhosphatesLigandsMolecular Docking SimulationMutant ProteinsMutationNeuropeptide YNuclear Magnetic Resonance, BiomolecularPhenylurea CompoundsProtein BindingReceptors, Neuropeptide YArginineBMS 193885DihydropyridinesDiphenylacetic AcidsInositol PhosphatesLigandsMutant ProteinsNalpha-diphenylacetyl-Nomega-(propionylaminoethyl)aminocarbonyl-(4-hydroxybenzyl)argininamideNeuropeptide Yneuropeptide Y-Y1 receptorPhenylurea CompoundsReceptors, Neuropeptide Y
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.