ArticleNature2018
Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells.
Abstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 56 citations in OpenAlex.
- Functional chromatin signatures premark future lineage-specific enhancers.Cell genomics · 2026Article
- Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome folding.Nature genetics · 2026Article
- Single-cell multi-omics analysis reveals cancer regulatory elements of transcriptional programs and clinical implications.Cell death & disease · 2025Article
- Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4.Nature communications · 2025Article
- Gastrula-Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross-Talk with TGF-β Signaling Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks.Genome biology · 2025Article
- Ligand-specific regulation of a binary enhancer code dictating cellular senescence.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dissecting the regulatory logic of specification and differentiation during vertebrate embryogenesis.bioRxiv : the preprint server for biology · 2024Article
- The molecular and cellular choreography of early mammalian lung development.Medical review (2021) · 2024Review
- Additional Sex Combs-like Family Associated with Epigenetic Regulation.International journal of molecular sciences · 2024Review
- Evolution of the enhancer-rich regulatory region of the gene for the cell-type specific transcription factor POU1F1.Heliyon · 2024Article
- Epigenomic states contribute to coordinated allelic transcriptional bursting in iPSC reprogramming.Life science alliance · 2024Article
- ZEB2 and MEIS1 independently contribute to hematopoiesis via early hematopoietic enhancer activation.iScience · 2023Article
- FACT regulates pluripotency through proximal and distal regulation of gene expression in murine embryonic stem cells.BMC biology · 2023Article
- Epigenetic Control of Cell Potency and Fate Determination during Mammalian Gastrulation.Genes · 2023Review
- Bcl6 drives stem-like memory macrophages differentiation to foster tumor progression.Cellular and molecular life sciences : CMLS · 2022Article
- Transcriptional enhancers at 40: evolution of a viral DNA element to nuclear architectural structures.Trends in genetics : TIG · 2022Review
- Long Noncoding RNAs in Cardiac Development.Cold Spring Harbor perspectives in biology · 2020Review
- IFI16 promotes human embryonic stem cell trilineage specification through interaction with p53.NPJ Regenerative medicine · 2020Article
- Transcription imparts architecture, function and logic to enhancer units.Nature genetics · 2020Article
Corrections and comments
- Commented on by
Authors and funding
11 authors at 2 institutions in 1 country.
Hong Sook KimHoward Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA. hsk020@ucsd.edu.
Yuliang TanHoward Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.
Wubin MaHoward Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.
Daria MerkurjevHoward Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.
Eugin DesticiHoward Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.
Qi MaHoward Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.
Tom SuterHoward Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.
Kenneth OhgiHoward Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.
Meyer FriedmanHoward Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.
Dorota Skowronska-KrawczykHoward Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.
Michael G RosenfeldHoward Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA. mrosenfeld@ucsd.edu.
University of California, San Diego · USHoward Hughes Medical Institute · US
Funding
HORMONAL AND DEVELOPMENTAL REGULATION OF GENE EXPRESSIONR01DK018477 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 1986 to 2025
$12.7MREGULATION OF NEUROENDOCRINE SWITCHING EVENTSR37DK039949 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 1987 to 2020
$12.3MCombinatorial Actions of Genetic Variants and Gender Bias of Alzherimer's DiseaseR01AG057706 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAGE, FRED H, GLASS, CHRISTOPHER K · 2017 to 2021
$8.1MRepressors in Prostate CancerR01CA097134 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 2002 to 2012
$3.2MNew Methods to Uncover Global Transcriptional Programs for Disease Risk VariantsR01GM104459 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SUH, YOUSIN · 2013 to 2016
$2.5MREGULATION OF NEUROENDOCRINE SWITCHING EVENTSR01DK039949 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 1996 to 2024
$2.4MChromosomal Boundary Alterations Driving Transcriptional Dysregulation in Brain DisordersR01NS093066 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 2016 to 2020
$2.4MRepressive Transcriptional Programs in Breast CancerR01CA213371 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 2017 to 2021
$755kHoward Hughes Medical InstituteNCI NIH HHS R01 CA097134NCI NIH HHS R01 CA213371NIA NIH HHS R01 AG057706NIDDK NIH HHS R01 DK018477NIDDK NIH HHS R01 DK039949NIDDK NIH HHS R37 DK039949NIGMS NIH HHS R01 GM104459NINDS NIH HHS R01 NS093066
Abstract
Enhancers for embryonic stem (ES) cell-expressed genes and lineage-determining factors are characterized by conventional marks of enhancer activation in ES cells
Indexed as
Enhancer Elements, GeneticAnimalsCell DifferentiationEpigenesis, GeneticFemaleGene Expression RegulationMacrophagesMiceMouse Embryonic Stem CellsNeural Stem CellsOrgan SpecificityPluripotent Stem CellsReproducibility of ResultsTranscription FactorsTranscription Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.