Evidence map›Paper›PMID 29670241›Full record

ArticleNature immunology2018

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.

Ayano C Kohlgruber, Shani T Gal-Oz, Nelson M LaMarche, Moto Shimazaki, Danielle Duquette, Hui-Fern Koay, Hung N Nguyen, Amir I Mina, Tyler Paras, Ali Tavakkoli and 7 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 202 papers.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

202 citing papers in PubMed, 315 citations in OpenAlex.

  1. Review
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  4. Adipocyte-derived LTB4 programs human NKG2AJournal for immunotherapy of cancer · 2026
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  14. Influence of Weight Loss and Weight Regain on Adipose Tissue Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. HEB collaborates with TCR signaling to upregulatebioRxiv : the preprint server for biology · 2025
    Article
  20. Review

142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 4 countries.

Ayano C KohlgruberDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA.
Shani T Gal-OzDepartment of Life Sciences, Ben-Gurion University of the Negev, Beersheba, Israel.
Nelson M LaMarcheDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA.
Moto ShimazakiDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA.
Danielle DuquetteDivision of Endocrinology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Hui-Fern KoayDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Australia.
Hung N NguyenDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA.
Amir I MinaDivision of Endocrinology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1231-1696
Tyler ParasDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA.
Ali TavakkoliDepartment of General and Gastrointestinal Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Ulrich von AndrianDivision of Medical Sciences, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4231-2283
Adam P UldrichDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Australia.
Dale I GodfreyDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Australia.
Alexander S BanksDivision of Endocrinology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1787-6925
Tal ShayDepartment of Life Sciences, Ben-Gurion University of the Negev, Beersheba, Israel.ORCID http://orcid.org/0000-0003-0755-1350
Michael B BrennerDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA. mbrenner@research.bwh.harvard.edu.ORCID http://orcid.org/0000-0001-6202-8445
Lydia LynchDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA. llynch@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-4273-4681
Brigham and Women's Hospital · USThe University of Melbourne · AUBen-Gurion University of the Negev · ILHarvard University · US

Funding

Supplement: Immunometabolic and epigenetic effects of obesity on innate immune surveillance in cancerR01AI134861 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LYNCH, LYDIA · 2018 to 2022
$2.9M
NIAID NIH HHS R01 AI134861NIH HHS R01 AI11304603
6 · The paper itself

Abstract

γδ T cells are situated at barrier sites and guard the body from infection and damage. However, little is known about their roles outside of host defense in nonbarrier tissues. Here, we characterize a highly enriched tissue-resident population of γδ T cells in adipose tissue that regulate age-dependent regulatory T cell (T

Indexed as

Adipose TissueAnimalsHomeostasisHumansInterleukin-17MaleMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-Cell, gamma-deltaThermogenesisT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsInterleukin-17Receptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID29670241
PMCPMC8299914
OpenAlexW2799881184

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.