Evidence map›Paper›PMID 29670239›Full record

ArticleNature immunology2018

Resistance of HIV-infected macrophages to CD8

Kiera L Clayton, David R Collins, Josh Lengieza, Musie Ghebremichael, Farokh Dotiwala, Judy Lieberman, Bruce D Walker

Abstract read
In one paragraph

Article in Nature immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 141 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. IBA-1Research square · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. HIV Cure: How Far We Have Come?Indian journal of microbiology · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kiera L ClaytonRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
David R CollinsRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Josh LengiezaRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Musie GhebremichaelRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Farokh DotiwalaProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Judy LiebermanProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Bruce D WalkerRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. bwalker@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-6122-9245
Ragon Institute of MGH, MIT and Harvard · USBoston Children's Hospital · USHoward Hughes Medical Institute · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Pathogenesis of Clade C HIV InfectionR37AI067073 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI WALKER, BRUCE D · 2011 to 2020
$6.6M
Molecular networks of HIV-specific CD4 T cell help to B cellsR01AI118544 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI WALKER, BRUCE D · 2015 to 2019
$2.2M
Characterization of CD8+ T cell killer activity and the mechanisms responsible for detachment from dead target cellsF32AI143480 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CLAYTON, KIERA L. · 2019 to 2020
$133k
Howard Hughes Medical InstituteNIAID NIH HHS F32 AI143480NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI118544NIAID NIH HHS R37 AI067073
6 · The paper itself

Abstract

CD4

Indexed as

CD4-Positive T-LymphocytesCells, CulturedCytotoxicity, ImmunologicHIV InfectionsHumansMacrophagesT-Lymphocytes, Cytotoxic

Identifiers

PMID29670239
PMCPMC6025741
OpenAlexW2797524595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.