ArticleScientific reports2018
The impact of genome variation and diet on the metabolic phenotype and microbiome composition of Drosophila melanogaster.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis suggests the microbiome responds to Evolve and Resequence experiments in Drosophila melanogaster.BMC microbiology · 2021Pooled it
- Host genetics and diet jointly shape the microbiome of Drosophila melanogaster but do not predict lifespan or age-related traits.Biogerontology · 2026Article
- Strain matters: host responses reflect symbiont origin in the squid-vibrio symbiosis.mSystems · 2025Article
- Microbial solutions to dietary stress: experimental evolution reveals host-microbiome interplay inProceedings. Biological sciences · 2025Article
- Different Long-Term Nutritional Regimens ofInsects · 2025Article
- Selection for stress tolerance and longevity in Drosophila melanogaster have strong impacts on microbiome profiles.Scientific reports · 2024Article
- Integrated stress response signaling acts as a metabolic sensor in fat tissues to regulate oocyte maturation and ovulation.Cell reports · 2024Article
- Gut Bacteriomes and Ecological Niche Divergence: An Example of Two Cryptic Gastropod Species.Biology · 2023Article
- Review
- Basidiomycota species in Drosophila gut are associated with host fat metabolism.Scientific reports · 2023Article
- The genetic basis of variation in immune defense against Lysinibacillus fusiformis infection in Drosophila melanogaster.PLoS pathogens · 2023Article
- Temporal dynamics and composition of ocular surface microbiota in C57BL/6J mice: uncovering a 12h ultradian rhythm.Frontiers in cellular and infection microbiology · 2023Article
- Life History Traits and Metabolic Pool Variation in Neotropical Species ofZoological studies · 2023Article
- Gut microbe Lactiplantibacillus plantarum undergoes different evolutionary trajectories between insects and mammals.BMC biology · 2022Article
- A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of Sirt1.G3 (Bethesda, Md.) · 2022Article
- Population bottlenecks constrain host microbiome diversity and genetic variation impeding fitness.PLoS genetics · 2022Article
- Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa.Physiological reports · 2022Article
- Article
- The impact of the gut microbiome on memory and sleep inThe Journal of experimental biology · 2021Article
- The Drosophila melanogaster Neprilysin Nepl15 is involved in lipid and carbohydrate storage.Scientific reports · 2021Article
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Authors and funding
4 authors.
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Abstract
The metabolic phenotype of an organism depends on a complex regulatory network, which integrates the plethora of intrinsic and external information and prioritizes the flow of nutrients accordingly. Given the rise of metabolic disorders including obesity, a detailed understanding of this regulatory network is in urgent need. Yet, our level of understanding is far from completeness and complicated by the discovery of additional layers in metabolic regulation, such as the impact of the microbial community present in the gut on the hosts' energy storage levels. Here, we investigate the interplay between genome variation, diet and the gut microbiome in the shaping of a metabolic phenotype. For this purpose, we reared a set of fully sequenced wild type Drosophila melanogaster flies under basal and nutritionally challenged conditions and performed metabolic and microbiome profiling experiments. Our results introduce the fly as a model system to investigate the impact of genome variation on the metabolic response to diet alterations and reveal candidate single nucleotide polymorphisms associated with different metabolic traits, as well as metabolite-metabolite and metabolite-microbe correlations. Intriguingly, the dietary changes affected the microbiome composition less than anticipated. These results challenge the current view of a rapidly changing microbiome in response to environmental fluctuations.
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