ArticleThe ISME journal2018
Micro-scale intermixing: a requisite for stable and synergistic co-establishment in a four-species biofilm.
Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Microbial Interactions Shape Spatial Organisation and Transcriptional Responses in a Model Mixed-Species Biofilm.Microbial ecology · 2026Article
- Influence of cell-cell distance on the ecology and evolution of microbial communities.The ISME journal · 2026Review
- Carbon substrate type shapes spatial self-organization in a multi-species biofilm community.The ISME journal · 2026Article
- Omics insights into the impact of slightly acidic electrolyzed water with sodium benzoate on food and oral associated microbes.Current research in food science · 2026Article
- Article
- Competition between Pseudomonas species constrains ecological diversification in polymicrobial biofilms.NPJ biofilms and microbiomes · 2025Article
- Article
- Disentangling the feedback loops driving spatial patterning in microbial communities.NPJ biofilms and microbiomes · 2025Review
- Synergistic biodegradation of polyethylene by experimentally evolved bacterial biofilms.The ISME journal · 2025Article
- Co-cultivation rescues suicidal Paenibacillus amylolyticus swarms.The ISME journal · 2025Article
- The contribution of antimicrobials and antimicrobial resistance to climate change and a possible way to reverse it whilst still offering high quality healthcare-a conceptual analysis.Frontiers in public health · 2025Review
- Time of first contact determines cooperator success in a three-member microbial consortium.ISME communications · 2025Article
- Optogenetic Control of Bacterial Cell-Cell Adhesion Dynamics: Unraveling the Influence on Biofilm Architecture and Functionality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Microfluidic approaches in microbial ecology.Lab on a chip · 2024Review
- Interspecific interactions facilitate keystone species in a multispecies biofilm that promotes plant growth.The ISME journal · 2024Article
- The biofilm community resurfaces: new findings and post-pandemic progress.Journal of bacteriology · 2023Review
- In Vitro Dental Plaque Culture Model for Biofilm Structural Analyses.Current protocols · 2023Article
- The ability of Phaeobacter inhibens to produce tropodithietic acid influences the community dynamics of a microalgal microbiome.ISME communications · 2022Article
- Droplet size and surface hydrophobicity enhance bacterial plasmid transfer rates in microscopic surface wetness.ISME communications · 2022Article
- Mechanisms underlying interactions between two abundant oral commensal bacteria.The ISME journal · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microorganisms frequently coexist in complex multispecies communities, where they distribute non-randomly, reflective of the social interactions that occur. It is therefore important to understand how social interactions and local spatial organization influences multispecies biofilm succession. Here the localization of species pairs was analyzed in three dimensions in a reproducible four-species biofilm model, to study the impact of spatial positioning of individual species on the temporal development of the community. We found, that as the biofilms developed, species pairs exhibited distinct intermixing patterns unique to the four-member biofilms. Higher biomass and more intermixing were found in four-species biofilms compared to biofilms with fewer species. Intriguingly, in local regions within the four member biofilms where Microbacterium oxydans was scant, both biomass and intermixing of all species were lowered, compared to regions where M. oxydans was present at typical densities. Our data suggest that Xanthomonas retroflexus and M. oxydans, both low abundant biofilm-members, intermixed continuously during the development of the four-species biofilm, hereby facilitating their own establishment. In turn, this seems to have promoted distinct spatial organization of Stenotrophomonas rhizophila and Paenibacillus amylolyticus enabling enhanced growth of all four species. Here local intermixing of bacteria advanced the temporal development of a multi-species biofilm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.