Evidence map›Paper›PMID 29670207›Full record

Trial reportBone marrow transplantation2018

Homeostatic proliferation leads to telomere attrition and increased PD-1 expression after autologous hematopoietic SCT for systemic sclerosis.

Lucas C M Arruda, João R Lima-Júnior, Emmanuel Clave, Daniela A Moraes, Corinne Douay, Isabelle Fournier, Hélène Moins-Teisserenc, Dimas T Covas, Belinda P Simões, Dominique Farge and 3 more

Open access · bronzeAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Bone marrow transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Side Effects of Immunosuppressant Drugs After Liver Transplant.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Observational
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Lucas C M ArrudaBasic and Applied Immunology Program, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0002-8573-9618
João R Lima-JúniorCenter for Cell-based Therapy, Regional Hemotherapy Center of the Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Emmanuel ClaveINSERM UMR-1160, Institut Universitaire d'Hématologie, Hôpital Saint-Louis-APHP, Paris, France.ORCID http://orcid.org/0000-0001-8217-5039
Daniela A MoraesDivision of Clinical Immunology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Corinne DouayINSERM UMR-1160, Institut Universitaire d'Hématologie, Hôpital Saint-Louis-APHP, Paris, France.
Isabelle FournierINSERM UMR-1160, Institut Universitaire d'Hématologie, Hôpital Saint-Louis-APHP, Paris, France.
Hélène Moins-TeisserencINSERM UMR-1160, Institut Universitaire d'Hématologie, Hôpital Saint-Louis-APHP, Paris, France.
Dimas T CovasCenter for Cell-based Therapy, Regional Hemotherapy Center of the Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Belinda P SimõesCenter for Cell-based Therapy, Regional Hemotherapy Center of the Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Dominique FargeINSERM UMR-1160, Institut Universitaire d'Hématologie, Hôpital Saint-Louis-APHP, Paris, France.
Antoine ToubertINSERM UMR-1160, Institut Universitaire d'Hématologie, Hôpital Saint-Louis-APHP, Paris, France.ORCID http://orcid.org/0000-0002-7308-7317
Kelen C R Malmegrim *Basic and Applied Immunology Program, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0002-9303-0086
Maria Carolina Oliveira *Basic and Applied Immunology Program, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. mcarolor@usp.br.ORCID http://orcid.org/0000-0003-0691-2222
Inserm · FRUniversidade de São Paulo · BRUniversidade de Ribeirão Preto · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the months that follow autologous hematopoietic stem cell transplantation (AHSCT), lymphopenia drives homeostatic proliferation, leading to oligoclonal expansion of residual cells. Here we evaluated how replicative senescent and exhausted cells associated with clinical outcomes of 25 systemic sclerosis (SSc) patients who underwent AHSCT. Patients were clinically monitored for skin (modified Rodnan's skin score, mRSS) and internal organ involvement and had blood samples collected before and semiannually, until 3 years post-AHSCT, for quantification of telomere length, CD8

Indexed as

Cell ProliferationHematopoietic Stem Cell TransplantationScleroderma, SystemicTelomere HomeostasisAdultCD8-Positive T-LymphocytesCytokinesFemaleFollow-Up StudiesHumansMaleMiddle AgedProgrammed Cell Death 1 ReceptorProspective StudiesTelomereTransplantation, AutologousCytokinesPDCD1 protein, humanProgrammed Cell Death 1 Receptor

Identifiers

PMID29670207
OpenAlexW2796737118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.