Evidence map›Paper›PMID 29670191›Full record

ArticleScientific reports2018

Fecal microbiota transplantation reverses antibiotic and chemotherapy-induced gut dysbiosis in mice.

Quentin Le Bastard, Tonya Ward, Dimitri Sidiropoulos, Benjamin M Hillmann, Chan Lan Chun, Michael J Sadowsky, Dan Knights, Emmanuel Montassier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.

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  20. Microbiome-induced increases and decreases in bone matrix strength can be initiated after skeletal maturity.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Quentin Le BastardUniversité de Nantes, Microbiotas Hosts Antibiotics and bacterial Resistances (MiHAR), Nantes, 44000, France.
Tonya WardBiotechnology Institute, University of Minnesota, Saint Paul, Minnesota, 55108, USA.
Dimitri SidiropoulosBiotechnology Institute, University of Minnesota, Saint Paul, Minnesota, 55108, USA.
Benjamin M HillmannDepartment of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, 55455, USA.
Chan Lan ChunBiotechnology Institute, University of Minnesota, Saint Paul, Minnesota, 55108, USA.ORCID 0000-0002-9765-8663
Michael J SadowskyBiotechnology Institute, University of Minnesota, Saint Paul, Minnesota, 55108, USA.ORCID 0000-0001-8779-2781
Dan KnightsBiotechnology Institute, University of Minnesota, Saint Paul, Minnesota, 55108, USA. dknights@umn.edu.
Emmanuel MontassierUniversité de Nantes, Microbiotas Hosts Antibiotics and bacterial Resistances (MiHAR), Nantes, 44000, France. emmanuel.montassier@chu-nantes.fr.ORCID 0000-0002-2313-1172
University of Minnesota · USNantes Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fecal microbiota transplantation (FMT) is now widely used to treat recurrent Clostridium difficile infection, but has been less studied as a means to restore microbiome diversity and composition following antibiotic or chemotherapy treatments. The purpose of our study was to assess the efficacy of FMT to reverse antibiotic- and chemotherapy-induced gut dysbiosis in a mouse model. C57BL/6J mice were treated with ampicillin for 1 week and/or received a single intraperitoneal injection of 5-Fluorouracil. Fresh stool was collected and analyzed using shotgun metagenomics and the Illumina sequencing platform. Ampicillin caused a significant and immediate decrease in bacterial species richness and diversity that persisted for one week. In mice that received FMT, disruption of the intestinal microbiota was reversed immediately. Antibiotic and chemotherapy administration caused significant alteration in species distribution, including a decrease in the relative proportions of Clostridium scindens and Faecalibacterium prausnitzii, and an increase in known pathogenic species. In mice receiving FMT, we observed a significant increase in species known to exhibit anti-inflammatory properties. Moreover, chemotherapy led to a critical decrease in key 'health-promoting' species and to an altered functional profile, especially when chemotherapy was administered in tandem with antibiotics, and that FMT can ameliorate these effects.

Indexed as

Fecal Microbiota TransplantationGastrointestinal MicrobiomeAnimalsAnti-Bacterial AgentsAntineoplastic AgentsBiodiversityDisease Models, AnimalDysbiosisFecesMetagenomeMetagenomicsMiceAnti-Bacterial AgentsAntineoplastic Agents

Identifiers

PMID29670191
PMCPMC5906603
OpenAlexW2800756579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.