Observational studyScientific reports2018
Preoperative Red Cell Distribution Width and 30-day mortality in older patients undergoing non-cardiac surgery: a retrospective cohort observational study.
Observational study in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The comparative and added prognostic value of biomarkers to the Revised Cardiac Risk Index for preoperative prediction of major adverse cardiac events and all-cause mortality in patients who undergo noncardiac surgery.The Cochrane database of systematic reviews · 2021Pooled it
- Elevated preoperative red cell distribution width and incident anemia after metabolic and bariatric surgery: a cohort study.Frontiers in nutrition · 2026Article
- Elevated preoperative red cell distribution width and incident infection after metabolic and bariatric surgery: a cohort study.Frontiers in nutrition · 2026Article
- Unmasking anemia in the elderly: A systematic review of prevalence, causes, and consequences.Journal of family medicine and primary care · 2025Review
- The association between preoperative anemia and postoperative mortality among non-cardiac surgical patients in Northwest Ethiopia: a prospective cohort study.BMC anesthesiology · 2025Article
- Association of preoperative red blood cell width and postoperative 30-day mortality in patients undergoing non-cardiac surgery: a retrospective cohort study using propensity-score matching.Perioperative medicine (London, England) · 2024Article
- Red Blood Cell Distribution Width is a Biomarker of Red Cell Dysfunction Associated with High Systemic Inflammation and a Prognostic Marker in Heart Failure and Cardiovascular Disease: A Potential Predictor of Atrial Fibrillation Recurrence.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Review
- Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies.Aging and disease · 2024Review
- Preoperative anemia in older individuals undergoing major abdominal surgery is associated with early postoperative morbidity: a prospective observational study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Observational
- Red cell distribution width and mortality in older patients with frailty in the emergency department.BMC emergency medicine · 2023Article
- Article
- Higher Preoperative Red Blood Cell Distribution Width Increases the Risk of Myocardial Injury After Noncardiac Surgery in Advanced-Age Patients: A Retrospective Cohort Study.Clinical interventions in aging · 2023Observational
- Association between red blood cell distribution width and mortality in patients with metastatic brain tumors: A retrospective single-center cohort study.Frontiers in oncology · 2022Article
- Exploring red cell distribution width as a potential risk factor in emergency bowel surgery-A retrospective cohort study.PloS one · 2022Article
- A Fast and Reliable Method to Interpret Short-Term Mortality in Perforated Peptic Ulcer: Red Cell Distribution Width is Sensitive and Specific.Surgery research and practice · 2021Article
- Red Cell Distribution Width as a Predictor of Functional Outcome in Rehabilitation of Older Stroke Patients.Annals of geriatric medicine and research · 2020Article
- A retrospective cohort study on the association between elevated preoperative red cell distribution width and all-cause mortality after noncardiac surgery.British journal of anaesthesia · 2020Article
- Getting patient blood management Pillar 1 right in the Asia-Pacific: a call for action.Singapore medical journal · 2020Review
- Red blood cell distribution width and outcomes following coronary artery bypass grafting: looking back and forth.Indian journal of thoracic and cardiovascular surgery · 2020Article
- Red Cell Volume Distribution Width as Another Biomarker.Cardiac failure review · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased red cell distribution width (RDW) is associated with poorer outcomes in various patient populations. We investigated the association between preoperative RDW and anaemia on 30-day postoperative mortality among elderly patients undergoing non-cardiac surgery. Medical records of 24,579 patients aged 65 and older who underwent surgery under anaesthesia between 1 January 2012 and 31 October 2016 were retrospectively analysed. Patients who died within 30 days had higher median RDW (15.0%) than those who were alive (13.4%). Based on multivariate logistic regression, in our cohort of elderly patients undergoing non-cardiac surgery, moderate/severe preoperative anaemia (aOR 1.61, p = 0.04) and high preoperative RDW levels in the 3rd quartile (>13.4% and ≤14.3%) and 4th quartile (>14.3%) were significantly associated with increased odds of 30-day mortality - (aOR 2.12, p = 0.02) and (aOR 2.85, p = 0.001) respectively, after adjusting for the effects of transfusion, surgical severity, priority of surgery, and comorbidities. Patients with high RDW, defined as >15.7% (90th centile), and preoperative anaemia have higher odds of 30-day mortality compared to patients with anaemia and normal RDW. Thus, preoperative RDW independently increases risk of 30-day postoperative mortality, and future risk stratification strategies should include RDW as a factor.
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