ArticleScientific reports2018
Structure and Properties of DNA Molecules Over The Full Range of Biologically Relevant Supercoiling States.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- hexABC seeking the physical code of DNA.Nature communications · 2026Article
- TOPO-seq reveals DNA topology-induced off-target activity by Cas9 and base editors.Nature chemical biology · 2025Article
- Depletion of CpG dinucleotides in bacterial genomes may represent an adaptation to high temperatures.NAR genomics and bioinformatics · 2024Article
- Differential roles of positive and negative supercoiling in organizing the E. coli genome.Nucleic acids research · 2024Article
- A catenane that is topologically achiral despite being composed of oriented rings.Nature chemistry · 2023Article
- An associative memory Hamiltonian model for DNA and nucleosomes.PLoS computational biology · 2023Article
- DNA Strand Breaks and Denaturation as Probes of Chemical Reactivity versus Thermal Effects of Atmospheric Pressure Plasma Jets.ACS omega · 2023Article
- Conformational deformation of a multi-jointed elastic loop.Scientific reports · 2022Article
- The flashfm approach for fine-mapping multiple quantitative traits.Nature communications · 2021Article
- Atomic force microscopy-A tool for structural and translational DNA research.APL bioengineering · 2021Review
- Genome-in-a-Box: Building a Chromosome from the Bottom Up.ACS nano · 2021Review
- Topoisomerases inhibition and DNA binding mode of daunomycin-oligoarginine conjugate.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- 3,6-Disubstituted 1,2,4-Triazolo[3,4-OncoTargets and therapy · 2020Article
- New Insights into Structural and Functional Roles of Indole-3-acetic acid (IAA): Changes in DNA Topology and Gene Expression in Bacteria.Biomolecules · 2019Article
- Application of Plasmid Engineering to Enhance Yield and Quality of Plasmid for Vaccine and Gene Therapy.Bioengineering (Basel, Switzerland) · 2019Article
- Twist to disentangle.Nature structural & molecular biology · 2019Article
- PICH and TOP3A cooperate to induce positive DNA supercoiling.Nature structural & molecular biology · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Topology affects physical and biological properties of DNA and impacts fundamental cellular processes, such as gene expression, genome replication, chromosome structure and segregation. In all organisms DNA topology is carefully modulated and the supercoiling degree of defined genome regions may change according to physiological and environmental conditions. Elucidation of structural properties of DNA molecules with different topology may thus help to better understand genome functions. Whereas a number of structural studies have been published on highly negatively supercoiled DNA molecules, only preliminary observations of highly positively supercoiled are available, and a description of DNA structural properties over the full range of supercoiling degree is lacking. Atomic Force Microscopy (AFM) is a powerful tool to study DNA structure at single molecule level. We here report a comprehensive analysis by AFM of DNA plasmid molecules with defined supercoiling degree, covering the full spectrum of biologically relevant topologies, under different observation conditions. Our data, supported by statistical and biochemical analyses, revealed striking differences in the behavior of positive and negative plasmid molecules.
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