ArticleScientific reports2018
Synergy between Diastolic Mitral Valve Function and Left Ventricular Flow Aids in Valve Closure and Blood Transport during Systole.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Two Faces of Mitral Stenosis: Uncovering Structural and Hemodynamic Signatures of Rheumatic and Mitral Annular Calcification-Induced Disease.Journal of the American Heart Association · 2026Article
- Toward precision in simulation of paediatric mitral valve repair using patient-specific fluid-structure interaction modelling.European heart journal. Imaging methods and practice · 2026Article
- Experimental and computational models for intracardiac flow analysis with blood speckle imaging.PloS one · 2026Article
- Intracardiac fluid dynamic analysis: available techniques and novel clinical applications.BMC cardiovascular disorders · 2024Review
- Biomechanical Analysis of Age-Dependent Changes in Fontan Power Loss.Annals of biomedical engineering · 2024Article
- Diastolic flow in the left ventricular outflow tract - A normal physiological and underappreciated echocardiographic finding.Australasian journal of ultrasound in medicine · 2022Article
- Clinical Impact of Computational Heart Valve Models.Materials (Basel, Switzerland) · 2022Review
- Improving transcatheter aortic valve interventional predictability via fluid-structure interaction modelling using patient-specific anatomy.Royal Society open science · 2022Article
- A CFD study on the interplay of torsion and vortex guidance by the mitral valve on the left ventricular wash-out making use of overset meshes (Chimera technique).Frontiers in medical technology · 2022Article
- Age-Related Changes in Left Ventricular Vortex Formation and Flow Energetics.Journal of clinical medicine · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
Highly resolved three-dimensional (3D) fluid structure interaction (FSI) simulation using patient-specific echocardiographic data can be a powerful tool for accurately and thoroughly elucidating the biomechanics of mitral valve (MV) function and left ventricular (LV) fluid dynamics. We developed and validated a strongly coupled FSI algorithm to fully characterize the LV flow field during diastolic MV opening under physiologic conditions. Our model revealed that distinct MV deformation and LV flow patterns developed during different diastolic stages. A vortex ring that strongly depended on MV deformation formed during early diastole. At peak E wave, the MV fully opened, with a local Reynolds number of ~5500, indicating that the flow was in the laminar-turbulent transitional regime. Our results showed that during diastasis, the vortex structures caused the MV leaflets to converge, thus increasing mitral jet's velocity. The vortex ring became asymmetrical, with the vortex structures on the anterior side being larger than on the posterior side. During the late diastolic stages, the flow structures advected toward the LV outflow tract, enhancing fluid transport to the aorta. This 3D-FSI study demonstrated the importance of leaflet dynamics, their effect on the vortex ring, and their influence on MV function and fluid transport within the LV during diastole.
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