Evidence map›Paper›PMID 29670127›Full record

SynthesisScientific reports2018

Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis.

Huifang Deng, Brecht Devleesschauwer, Mingyuan Liu, Jianhua Li, Yongning Wu, Joke W B van der Giessen, Marieke Opsteegh

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Systematic review and modelling ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Pooled it
  2. Deciphering the epidemiological dynamics:Frontiers in cellular and infection microbiology · 2024
    Pooled it
  3. Pooled it
  4. Seroprevalence ofJournal of veterinary science · 2022
    Pooled it
  5. Global Status ofFrontiers in veterinary science · 2020
    Pooled it
  6. Seroprevalence ofVeterinary sciences · 2026
    Article
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  11. Review
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  18. Pathomechanisms in the Kidneys in Selected Protozoan Parasitic Infections.International journal of molecular sciences · 2021
    Review
  19. Article
  20. Prevalence of Anti-Frontiers in reproductive health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Huifang DengCentre for Infectious Disease Control - Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment, 3720 BA, Bilthoven, Netherlands.ORCID 0000-0002-4880-760X
Brecht DevleesschauwerDepartment of Public Health and Surveillance, Scientific Institute of Public Health (WIV-ISP), 1050, Brussels, Belgium.ORCID 0000-0002-2867-6892
Mingyuan LiuInstitute of Zoonosis, Jilin University, 130062, Changchun, People's Republic of China.
Jianhua LiInstitute of Zoonosis, Jilin University, 130062, Changchun, People's Republic of China.
Yongning WuKey Laboratory of China Food Safety Risk Assessment, National Center for Food Safety Risk Assessment, 100022, Beijing, People's Republic of China.
Joke W B van der GiessenCentre for Infectious Disease Control - Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment, 3720 BA, Bilthoven, Netherlands.
Marieke OpsteeghCentre for Infectious Disease Control - Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment, 3720 BA, Bilthoven, Netherlands. marieke.opsteegh@rivm.nl.
National Institute for Public Health and the Environment · NLJilin University · CNChina National Center for Food Safety Risk Assessment · CNInstitut Scientifique de Santé Publique · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary Toxoplasma gondii infection in pregnant women may result in abortion, stillbirth, or lifelong disabilities of the unborn child. One of the main transmission routes to humans is consumption of raw or undercooked meat containing T. gondii tissue cysts. We aim to determine and compare the regional distribution of T. gondii seroprevalence in pregnant women and meat-producing livestock in China through a systematic literature review. A total of 272 eligible publications were identified from Medline, Scopus, Embase and China National Knowledge Infrastructure. Apparent and true seroprevalence were analysed by region using a novel Bayesian hierarchical model that allowed incorporating sensitivity and specificity of the applied serological assays. The true seroprevalence of T. gondii in pregnant women was 5.0% or less in seven regions of China. The median of the regional true seroprevalences in pigs (24%) was significantly higher than in cattle (9.5%), but it was not significantly higher than in chickens (20%) and small ruminants (20%). This study represents the first use of a Bayesian hierarchical model to obtain regional true seroprevalence. These results, in combination with meat consumption data, can be used to better understand the contribution of meat-producing animals to human T. gondii infection in China.

Indexed as

Pregnancy ComplicationsToxoplasmaAdultAnimalsAntibodies, ProtozoanBayes TheoremCattleChickensChinaFemaleGeography, MedicalHumansImmunoassayLivestockParasitic Diseases, AnimalPregnancyAntibodies, Protozoan

Identifiers

PMID29670127
PMCPMC5906581
OpenAlexW2799962261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.