ArticleNature communications2018
Olfactory inputs modulate respiration-related rhythmic activity in the prefrontal cortex and freezing behavior.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.
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Who cites it
100 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inconclusive evidence that breathing shapes pupil dynamics in humans: a systematic review.Pflugers Archiv : European journal of physiology · 2023Pooled it
- A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The effect of nasal olfactory stimulation on apnea of prematurity: a randomized cross-over trial.Pediatric research · 2026Article
- Dexterous single sniffs for ethological active olfaction.Science advances · 2026Article
- The representational geometry of emotional states in basolateral amygdala.Nature neuroscience · 2026Article
- An olfactory-prefrontal cortical circuit supports social recognition.Research square · 2026Article
- Generalization of fear learning is shaped by inhibitory sensory processing in mice.Nature communications · 2026Article
- Dynamic Respiration-Neural Coupling in Substantia Nigra across Sleep and Anesthesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The human brain modulates sniffs according to fine-grained perceptual features of odours.Nature human behaviour · 2026Article
- How do we think and what is the neural circuit mechanism for it? Possible roles of working memory and inner speech in thinking.Frontiers in human neuroscience · 2026Article
- Article
- Respiration-coordinated attentional switch from feedforward to top-down informational flow directed by the basal forebrain: layer-specific blanket inhibition of pyramidal cells by neurogliaform cells in the piriform cortex.Frontiers in neural circuits · 2026Review
- AAV9-mediated transduction of memory circuits following convection-enhanced delivery into the olfactory bulbs.Gene therapy · 2025Article
- Nasal respiration modulates pain perception via the olfactory Bulb-Anterior cingulate cortex circuit.iScience · 2025Article
- Mouse olfactory system acts as anemo-detector and anemo-discriminator.Science advances · 2025Article
- Directing negative emotional states through parallel genetically-distinct basolateral amygdala pathways to ventral striatum subregions.Molecular psychiatry · 2025Article
- Effects of Olfactory Valence on the Neural and Behavioral Dynamics of Approach-Avoidance: An EEG Study.Brain sciences · 2025Article
- Hippocampal-Prefrontal Communication Subspaces Align with Behavioral and Network Patterns in a Spatial Memory Task.eNeuro · 2025Article
- Dynamic brain-heart interaction in sleep characterized by variational phase-amplitude coupling framework.Communications biology · 2025Article
- Developmental Olfactory Dysfunction and Abnormal Odor Memory in Immune-ChallengedThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
Respiration and airflow through the nasal cavity are known to be correlated with rhythmic neural activity in the central nervous system. Here we show in rodents that during conditioned fear-induced freezing behavior, mice breathe at a steady rate (~4 Hz), which is correlated with a predominant 4-Hz oscillation in the prelimbic prefrontal cortex (plPFC), a structure critical for expression of conditioned fear behaviors. We demonstrate anatomical and functional connections between the olfactory pathway and plPFC via circuit tracing and optogenetics. Disruption of olfactory inputs significantly reduces the 4-Hz oscillation in the plPFC, but leads to prolonged freezing periods. Our results indicate that olfactory inputs can modulate rhythmic activity in plPFC and freezing behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.