Evidence map›Paper›PMID 29670093›Full record

ArticleEmerging microbes & infections2018

Wild ducks excrete highly pathogenic avian influenza virus H5N8 (2014-2015) without clinical or pathological evidence of disease.

Judith M A van den Brand, Josanne H Verhagen, Edwin J B Veldhuis Kroeze, Marco W G van de Bildt, Rogier Bodewes, Sander Herfst, Mathilde Richard, Pascal Lexmond, Theo M Bestebroer, Ron A M Fouchier and 1 more

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Judith M A van den BrandDepartment of Viroscience, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Josanne H VerhagenDepartment of Viroscience, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Edwin J B Veldhuis KroezeDepartment of Viroscience, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Marco W G van de BildtDepartment of Viroscience, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Rogier BodewesDepartment of Viroscience, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Sander HerfstDepartment of Viroscience, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Mathilde RichardDepartment of Viroscience, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Pascal LexmondDepartment of Viroscience, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Theo M BestebroerDepartment of Viroscience, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Ron A M FouchierDepartment of Viroscience, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Thijs KuikenDepartment of Viroscience, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. t.kuiken@erasmusmc.nl.
Viroclinics Biosciences (Netherlands) · NLErasmus MC · NLLinnaeus University · SE

Funding

NIAID NIH HHS HHSN272201400008C
6 · The paper itself

Abstract

Highly pathogenic avian influenza (HPAI) is essentially a poultry disease. Wild birds have traditionally not been involved in its spread, but the epidemiology of HPAI has changed in recent years. After its emergence in southeastern Asia in 1996, H5 HPAI virus of the Goose/Guangdong lineage has evolved into several sub-lineages, some of which have spread over thousands of kilometers via long-distance migration of wild waterbirds. In order to determine whether the virus is adapting to wild waterbirds, we experimentally inoculated the HPAI H5N8 virus clade 2.3.4.4 group A from 2014 into four key waterbird species-Eurasian wigeon (Anas penelope), common teal (Anas crecca), mallard (Anas platyrhynchos), and common pochard (Aythya ferina)-and compared virus excretion and disease severity with historical data of the HPAI H5N1 virus infection from 2005 in the same four species. Our results showed that excretion was highest in Eurasian wigeons for the 2014 virus, whereas excretion was highest in common pochards and mallards for the 2005 virus. The 2014 virus infection was subclinical in all four waterbird species, while the 2005 virus caused clinical disease and pathological changes in over 50% of the common pochards. In chickens, the 2014 virus infection caused systemic disease and high mortality, similar to the 2005 virus. In conclusion, the evidence was strongest for Eurasian wigeons as long-distance vectors for HPAI H5N8 virus from 2014. The implications of the switch in species-specific virus excretion and decreased disease severity may be that the HPAI H5 virus more easily spreads in the wild-waterbird population.

Indexed as

Virus SheddingAnimal MigrationAnimalsAnimals, WildCloacaDisease OutbreaksDucksEpidemiological MonitoringInfluenza A Virus, H5N8 SubtypeInfluenza in BirdsPhylogeny

Identifiers

PMID29670093
PMCPMC5906613
OpenAlexW2807668996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.