ArticleInternational journal of environmental research and public health2018
Stress and Alterations in the Pain Matrix: A Biopsychosocial Perspective on Back Pain and Its Prevention and Treatment.
Article in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Use and efficacy of virtual, augmented, or mixed reality technology for chronic pain: a systematic review.Pain management · 2022Pooled it
- Stress Characteristics and Their Associations With Pain Intensity: An Ecological Momentary Assessment Study.European journal of pain (London, England) · 2026Article
- Pain science knowledge among healthcare Professionals: A cross-sectional survey within the United States Department of Veterans Affairs.Musculoskeletal science & practice · 2025Article
- Factors and their age differences associated with low back pain among Japanese workers: a cross-sectional study.Industrial health · 2025Article
- Opioid-use disorder and reported pain after spine surgery: Risk-group patterns in cognitive-appraisal processes in a longitudinal cohort study.North American Spine Society journal · 2025Article
- The association of different types of stress, and stress accumulation with low back pain in call-center workers - a cross-sectional observational study.BMC musculoskeletal disorders · 2024Observational
- The Role of Mindfulness Therapy in the Treatment of Chronic Pain.Current pain and headache reports · 2024Review
- Insights into pain distraction and the impact of pain catastrophizing on pain perception during different types of distraction tasks.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Associations Between Temporomandibular Pain and Biobehavioral Variables in Dental Students in Response to an External Stressor.Journal of oral & facial pain and headache · 2023Article
- Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study.Frontiers in nutrition · 2023Article
- Emotional Imagery Influences the Adaptive Force in Young Women: Unpleasant Imagery Reduces Instantaneously the Muscular Holding Capacity.Brain sciences · 2022Article
- The Role of Pain Inflexibility and Acceptance among Headache and Temporomandibular Disorders Patients.International journal of environmental research and public health · 2022Article
- Stress and Pain. Predictive (Neuro)Pattern Identification for Chronic Back Pain: A Longitudinal Observational Study.Frontiers in medicine · 2022Article
- Training intervention effects on cognitive performance and neuronal plasticity-A pilot study.Frontiers in neurology · 2022Article
- RENaBack: low back pain patients in rehabilitation-study protocol for a multicenter, randomized controlled trial.Trials · 2021Article
- The impact of foot shock-induced stress on pain-related behavior associated with burn injury.Burns : journal of the International Society for Burn Injuries · 2021Article
- Nitric Oxide in the Spinal Cord Is Involved in the Hyperalgesia Induced by Tetrahydrobiopterin in Chronic Restraint Stress Rats.Frontiers in neuroscience · 2021Article
- Sustainability of a Motor Control Exercise Intervention: Analysis of Long-Term Effects in a Low Back Pain Study.Frontiers in sports and active living · 2021Article
- Psychosocial Moderators and Mediators of Sensorimotor Exercise in Low Back Pain: A Randomized Multicenter Controlled Trial.Frontiers in psychiatry · 2021Article
- Motor Control Stabilisation Exercise for Patients with Non-Specific Low Back Pain: A Prospective Meta-Analysis with Multilevel Meta-Regressions on Intervention Effects.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genesis of chronic pain is explained by a biopsychosocial model. It hypothesizes an interdependency between environmental and genetic factors provoking aberrant long-term changes in biological and psychological regulatory systems. Physiological effects of psychological and physical stressors may play a crucial role in these maladaptive processes. Specifically, long-term demands on the stress response system may moderate central pain processing and influence descending serotonergic and noradrenergic signals from the brainstem, regulating nociceptive processing at the spinal level. However, the underlying mechanisms of this pathophysiological interplay still remain unclear. This paper aims to shed light on possible pathways between physical (exercise) and psychological stress and the potential neurobiological consequences in the genesis and treatment of chronic pain, highlighting evolving concepts and promising research directions in the treatment of chronic pain. Two treatment forms (exercise and mindfulness-based stress reduction as exemplary therapies), their interaction, and the dose-response will be discussed in more detail, which might pave the way to a better understanding of alterations in the pain matrix and help to develop future prevention and therapeutic concepts.
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