Trial reportProceedings of the National Academy of Sciences of the United States of America2018
Mutations in the pancreatic secretory enzymes
Open access · bronzeAbstract readClinical Trial, Phase IClinical Trial, Phase IIMulticenter Study
In one paragraph
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Modern Approaches to Diagnosis and Evaluation of Survival Prognosis in Patients with Pancreatic Cancer.International journal of molecular sciences · 2026Pooled it
- Endoplasmic stress-inducing variants in CPB1 and CPA1 and risk of pancreatic cancer: A case-control study and meta-analysis.International journal of cancer · 2022Pooled it
- Specificity-driven cell-gene graph learning identifies rare cell states in single-cell and spatial transcriptomic data.Advanced biotechnology · 2026Article
- CSIE: cancer subtyping via inference and ensemble.Briefings in bioinformatics · 2026Article
- Hypergraph representations of single-cell RNA sequencing data for improved cell clustering.Bioinformatics (Oxford, England) · 2026Article
- Article
- Single-Cell Transcriptomics Identifies BST2 as an Oncogenic Driver and Immunotherapy Biomarker in Lung Adenocarcinoma.Mediators of inflammation · 2026Article
- MisfoldingAmerican journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Established Cancer Predisposition Genes in Single and Multiple Cancer Diagnoses.JAMA oncology · 2025Article
- Article
- Article
- Comprehensive analysis of differential mRNA and circRNA profiles in primary and metastatic pancreatic neuroendocrine tumors.Biochemistry and biophysics reports · 2025Article
- A lectin produced by a Streptomyces species targets mammalian pancreatic acinar cells in mice and humans.Scientific reports · 2025Article
- Understanding familial risk of pancreatic ductal adenocarcinoma.Familial cancer · 2024Review
- Genotypes of carboxypeptidase A1 and gamma-glutamyltransferase 1 may be useful tools for the diagnosis and the predictor of worrisome features of intraductal papillary mucinous neoplasm in Japan.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Article
- Circulating pancreatic enzyme levels are a causal biomarker of type 1 diabetes.medRxiv : the preprint server for health sciences · 2024Article
- Genetic and other risk factors for pancreatic ductal adenocarcinoma (PDAC).Familial cancer · 2024Review
- The role of biomarkers in the early detection of pancreatic cancer.Familial cancer · 2024Review
- Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma.GigaScience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 11 institutions in 2 countries.
Koji TamuraDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0003-1534-9275
Jun YuDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Tatsuo HataDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Masaya SuenagaDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Koji ShindoDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Toshiya AbeDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Anne MacGregor-DasDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Michael BorgesDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Christopher L WolfgangDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Matthew J WeissDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Jin HeDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Marcia Irene CantoThe Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Gloria M PetersenHealth Sciences Research, Mayo Clinic, Rochester, MN 55905.
Steven GallingerSamuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5.
Sapna SyngalPopulation Sciences Division, Dana-Farber Cancer Institute, Boston, MA 02215.
Randall E BrandDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213.
Anil RustgiDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10017.
Elena StoffelDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Michele L CoteKarmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201.
George ZogopoulosThe Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada H3H 2R9.
James B PotashDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Richard W McCombieStanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.
Peter P ZandiDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Mehdi PiroozniaDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Melissa KramerStanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.
Jennifer ParlaStanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.
James R EshlemanDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Nicholas J RobertsDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Ralph H HrubanDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Alison Patricia KleinDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Michael GogginsDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; mgoggins@jhmi.edu.
Johns Hopkins University · USCold Spring Harbor Laboratory · USDana-Farber Cancer Institute · USMayo Clinic in Florida · USMcGill University Health Centre · CAMemorial Sloan Kettering Cancer Center · USMount Sinai Hospital · CAUniversity of Michigan · USUniversity of Pennsylvania · USUniversity of Pittsburgh · USWayne State University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MSingle-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9MTumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI JAFFEE, ELIZABETH M. · 1993 to 2022
$54.6MTissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI MUKHOPADHYAY, DEBABRATA · 2004 to 2018
$32.7MUsing markers to improve pancreatic cancer screening and surveillance: a multi-center studyU01CA210170 · NCI · JOHNS HOPKINS UNIVERSITY · PI Michael G. Goggins · 2016 to 2026
$9.3MBioinformatics CoreZICHL006228 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI PIROOZNIA, MEHDI · 2017 to 2021
$6.6MValidation and Fine-Scale Mapping of Pancreatic Cancer Susceptibility Loci (Study)R01CA154823 · NCI · JOHNS HOPKINS UNIVERSITY · PI KLEIN, ALISON P · 2011 to 2020
$5.7MValidation and extension of the PREMM Model for mismatch repair gene mutationsR01CA132829 · NCI · DANA-FARBER CANCER INST · PI SYNGAL, SAPNA · 2008 to 2022
$5.6MUsing Markers to Improve Pancreatic Cancer ScreeningR01CA176828 · NCI · JOHNS HOPKINS UNIVERSITY · PI GOGGINS, MICHAEL G. · 2013 to 2024
$4.1MIntegrative Analyses to Identify Pancreatic Cancer Susceptibility GenesR00CA190889 · NCI · JOHNS HOPKINS UNIVERSITY · PI ROBERTS, NICHOLAS JASON · 2017 to 2019
$747kIntegrative Analyses to Identify Pancreatic Cancer Susceptibility GenesK99CA190889 · NCI · JOHNS HOPKINS UNIVERSITY · PI ROBERTS, NICHOLAS JASON · 2015 to 2016
$172kNCI NIH HHS K99 CA190889NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA022453NCI NIH HHS P30 CA045508NCI NIH HHS P50 CA062924NCI NIH HHS P50 CA102701NCI NIH HHS R00 CA190889NCI NIH HHS R01 CA132829NCI NIH HHS R01 CA154823NCI NIH HHS R01 CA176828NCI NIH HHS U01 CA210170
Abstract
To evaluate whether germline variants in genes encoding pancreatic secretory enzymes contribute to pancreatic cancer susceptibility, we sequenced the coding regions of
Indexed as
Carboxypeptidase BCarboxypeptidases AGenetic Predisposition to DiseaseMutationNeoplasm ProteinsPancreatic NeoplasmsAgedAged, 80 and overCell Line, TumorEndoplasmic Reticulum StressFemaleHumansMaleMiddle AgedCarboxypeptidase BCarboxypeptidases ACPB1 protein, humanNeoplasm ProteinsCPA1CPB1ER stresspancreatic cancerpancreatitis
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.