Evidence map›Paper›PMID 29669909›Full record

ArticleNeurology2018

Time course of blood pressure control prior to lacunar TIA and stroke: Population-based study.

Linxin Li, Sarah J V Welch, Sergei A Gutnikov, Ziyah Mehta, Peter M Rothwell, Oxford Vascular Study

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Linxin LiFrom the Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience University of Oxford, UK.
Sarah J V WelchFrom the Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience University of Oxford, UK.
Sergei A GutnikovFrom the Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience University of Oxford, UK.
Ziyah MehtaFrom the Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience University of Oxford, UK.
Peter M RothwellFrom the Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience University of Oxford, UK. Peter.rothwell@ndcn.ox.ac.uk.
Oxford Vascular Study
UK Dementia Research Institute · GB

Funding

British Heart Foundation
6 · The paper itself

Abstract

objectiveTo determine the age-specific temporal trends in blood pressure (BP) before acute lacunar vs nonlacunar TIA and stroke.

methodsIn a population-based study of TIA/ischemic stroke (Oxford Vascular Study), we studied 15-year premorbid BP readings from primary care records in patients with lacunar vs nonlacunar events (Trial of Org 10172 in Acute Stroke Treatment [TOAST]) stratified by age (<65, ≥65 years).

resultsOf 2,085 patients (1,250 with stroke, 835 with TIA), 309 had lacunar events. In 493 patients <65 years of age, the prevalence of diagnosed hypertension did not differ between lacunar and nonlacunar events (46 [48.4%] vs 164 [41.2%],

conclusionRecent premorbid BP control is strongly temporarily related to acute lacunar events at younger ages, suggesting a direct role of BP in accelerating causal pathology and highlighting the need to control hypertension quickly.

Indexed as

AgedAged, 80 and overAge FactorsAntihypertensive AgentsBlood PressureBlood Pressure DeterminationCohort StudiesCommunity Health PlanningFemaleHumansHypertensionIschemic Attack, TransientMaleMiddle AgedStroke, LacunarTime FactorsAntihypertensive Agents

Identifiers

PMID29669909
PMCPMC5957302
OpenAlexW2800873284

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.