ArticleNeurology2018
Cortical and subcortical gray matter bases of cognitive deficits in REM sleep behavior disorder.
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Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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53citing papers in PubMed, 1 pooled it
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Neuropsychological Changes in Isolated REM Sleep Behavior Disorder: A Systematic Review and Meta-analysis of Cross-sectional and Longitudinal Studies.Neuropsychology review · 2024Pooled it
- Trial
- Discordance Between Striatal Dopaminergic Imaging and Motor Performances in REM Sleep Behavior Disorder.Neurology open access · 2026Article
- Cortical and subcortical gray matter alterations underlying sleep disturbances in patients with end-stage renal disease undergoing hemodialysis.Brain imaging and behavior · 2026Article
- Depression and cognition mediated rapid eye movement sleep behavior disorder to improve the activities of daily living in Parkinson's disease patients.Frontiers in psychiatry · 2026Article
- Imaging biomarkers in neurodegenerative diseases: advances and challenges.Frontiers in aging neuroscience · 2026Review
- MRI structural and functional axial asymmetry in the brain-first versus body-first subtypes of Parkinson's disease.NPJ Parkinson's disease · 2025Article
- REM Sleep Behavior Disorder as a Prodromal Synucleinopathy: Updates on Clinical and Laboratory Biomarkers, and Implications for Neuroprotective Trials.Current neurology and neuroscience reports · 2025Review
- Estrogen-related receptor gene expression associates with sex differences in cortical atrophy in isolated REM sleep behavior disorder.Nature communications · 2025Article
- Altered network efficiency in isolated REM sleep behavior disorder: A multicentric study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Colour discrimination deficit in REM sleep behavior disorder: an analysis of dopaminergic depletion, cognition, and brain morphology.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder.NPJ Parkinson's disease · 2025Article
- Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder.NPJ Parkinson's disease · 2025Article
- A Narrative Review on Biochemical Markers and Emerging Treatments in Prodromal Synucleinopathies.Clinics and practice · 2025Review
- Thalamic Structural Connectivity Alterations in Essential Tremor Associated with REM Sleep Behaviour Disorder.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Cuneus atrophy and Parkinsonian phenoconversion in cognitively unimpaired patients with isolated REM sleep behavior disorder.Journal of neurology · 2024Article
- Children with Congenital Heart Diseases Exhibit Altered Deep Gray Matter Structures.Clinical neuroradiology · 2024Article
- Article
- Sex-specific grey matter abnormalities in individuals with chronic insomnia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Neuroanatomical findings in isolated REM sleep behavior disorder and early Parkinson's disease: a Voxel-based morphometry study.Brain imaging and behavior · 2024Article
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Authors and funding
12 authors at 1 institution in 1 country.
Shady RahayelFrom the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France.
Ronald B PostumaFrom the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France.
Jacques MontplaisirFrom the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France.
Daphné Génier MarchandFrom the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France.
Frédérique EscudierFrom the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France.
Malo GaubertFrom the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France.
Pierre-Alexandre BourgouinFrom the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France.
Julie CarrierFrom the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France.
Oury MonchiFrom the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France.
Sven JoubertFrom the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France.
Frédéric BlancFrom the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France.
Jean-François GagnonFrom the Centre for Advanced Research in Sleep Medicine (S.R., R.B.P., J.M., D.G.M., M.G., P.-A.B., J.C., J.-F.G.), Hôpital du Sacré-Cœur de Montréal; Department of Psychology (S.R., D.G.M., M.G., P.-A.B., J.-F.G.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Departments of Psychiatry (J.M.), Psychology (F.E., J.C., S.J.), and Radiology, Radio-Oncology, and Nuclear Medicine (O.M.), Université de Montréal; Research Centre (F.E., J.C., O.M., S.J., J.-F.G.), Institut universitaire de gériatrie de Montréal; Departments of Clinical Neurosciences and Radiology (O.M.), and Hotchkiss Brain Institute, University of Calgary, Canada; Université de Strasbourg and CNRS (F.B.), ICube UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS, Strasbourg; and Saint François Day Hospital, Department of Geriatrics (F.B.), and Memory Resources and Research Centre (CM2R), Departments of Geriatrics and Neurology (F.B.), Hôpitaux Universitaires de Strasbourg, France. gagnon.jean-francois.2@uqam.ca.
University of Calgary · CA
Funding
CIHR
Abstract
objectiveTo investigate cortical and subcortical gray matter abnormalities underlying cognitive impairment in patients with REM sleep behavior disorder (RBD) with or without mild cognitive impairment (MCI).
methodsFifty-two patients with RBD, including 17 patients with MCI, were recruited and compared to 41 controls. All participants underwent extensive clinical assessments, neuropsychological examination, and 3-tesla MRI acquisition of T1 anatomical images. Vertex-based cortical analyses of volume, thickness, and surface area were performed to investigate cortical abnormalities between groups, whereas vertex-based shape analysis was performed to investigate subcortical structure surfaces. Correlations were performed to investigate associations between cortical and subcortical metrics, cognitive domains, and other markers of neurodegeneration (color discrimination, olfaction, and autonomic measures).
resultsPatients with MCI had cortical thinning in the frontal, cingulate, temporal, and occipital cortices, and abnormal surface contraction in the lenticular nucleus and thalamus. Patients without MCI had cortical thinning restricted to the frontal cortex. Lower patient performance in cognitive domains was associated with cortical and subcortical abnormalities. Moreover, impaired performance on olfaction, color discrimination, and autonomic measures was associated with thinning in the occipital lobe.
conclusionsCortical and subcortical gray matter abnormalities are associated with cognitive status in patients with RBD, with more extensive patterns in patients with MCI. Our results highlight the importance of distinguishing between subgroups of patients with RBD according to cognitive status in order to better understand the neurodegenerative process in this population.
Indexed as
AgedBlood PressureBrainCognition DisordersFemaleGray MatterHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedNeurologic ExaminationNeuropsychological TestsPolysomnographyREM Sleep Behavior DisorderSmell
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