Evidence map›Paper›PMID 29669889›Full record

ArticlemSphere2018

Molecular Preadaptation to Antimony Resistance in Leishmania donovani on the Indian Subcontinent.

F Dumetz, B Cuypers, H Imamura, D Zander, E D'Haenens, I Maes, M A Domagalska, J Clos, J-C Dujardin, G De Muylder

Abstract read
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Targeting p53 pathways: mechanisms, structures, and advances in therapy.Signal transduction and targeted therapy · 2023
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Unraveling the Genome Diversity ofLife (Basel, Switzerland) · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Effects of chitosan-titanium dioxide-Glucantime nanoassemblies onIranian journal of basic medical sciences · 2025
    Article
  15. Article
  16. Genome analyses of amphotericin B-susceptible and -resistant strains ofCurrent research in parasitology & vector-borne diseases · 2025
    Article
  17. Molecular Mechanisms of Drug Resistance inPathogens (Basel, Switzerland) · 2024
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

F DumetzMolecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium.ORCID https://orcid.org/0000-0001-8790-9986
B CuypersMolecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium.ORCID https://orcid.org/0000-0002-7198-1470
H ImamuraMolecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium.
D ZanderBernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
E D'HaenensMolecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium.
I MaesMolecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium.
M A DomagalskaMolecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium.
J ClosBernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
J-C DujardinMolecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium jcdujardin@itg.be gdemuylder@itg.be.
G De MuylderMolecular Parasitology, Institute of Tropical Medicine, Antwerp, Belgium jcdujardin@itg.be gdemuylder@itg.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimonials (Sb) were used for decades for chemotherapy of visceral leishmaniasis (VL). Now abandoned in the Indian subcontinent (ISC) because of

Indexed as

AntimonyAntimony Potassium TartrateAntiprotozoal AgentsDrug ResistanceGenetic VariationGenomicsHumansIndiaLeishmania donovaniLeishmaniasis, VisceralMetabolomicsNepalProtozoan ProteinsAntimonyAntimony Potassium TartrateAntiprotozoal AgentsProtozoan Proteinsantimonialsdrug resistance mechanismsgenomicsLeishmaniametabolomics

Identifiers

PMID29669889
PMCPMC5907651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.