ArticleJournal of neurointerventional surgery2018
The LUNA aneurysm embolization system for intracranial aneurysm treatment: short-term, mid-term and long-term clinical and angiographic results.
Article in Journal of neurointerventional surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The trial behind it
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- New Artisse intrasaccular device for intracranial aneurysm treatment: short term clinical and angiographic result from the prospective registry INSPIRE-A.Journal of neurointerventional surgery · 2026Article
- Retrospective multicenter analysis of the Trenza Embolization Device for endovascular therapy of intracranial aneurysms: initial results and short-term follow-up.Journal of neurointerventional surgery · 2025Article
- 15 years of WEB embolization: a transformative journey in aneurysm treatment.Journal of neurointerventional surgery · 2025Article
- A review and journey in intrasaccular treatment of intracranial aneurysms.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Review
- Endovascular Treatment of Wide-Neck Intracranial Aneurysms Using the Novel Contour Neurovascular System: 5-Year Follow-up.AJNR. American journal of neuroradiology · 2025Article
- The Artisse Intrasaccular Device: A New Intrasaccular Flow Diverter for the Treatment of Cerebral Aneurysms.AJNR. American journal of neuroradiology · 2025Article
- Intrasaccular therapy in wide-neck intracranial aneurysms: a narrative review.Frontiers in neurology · 2025Review
- Intrasaccular Treatment of Intracranial Aneurysms: A Comprehensive Review.Journal of clinical medicine · 2024Review
- Initial Experiences with the Trenza Embolization Device for the Treatment of Wide-Neck Intracranial Aneurysms: A 12-Patient Case Series.AJNR. American journal of neuroradiology · 2024Observational
- Systematic Review and Meta-Analysis of Endovascular Therapy Effectiveness for Unruptured Saccular Intracranial Aneurysms.Stroke (Hoboken, N.J.) · 2024Article
- A new era in the treatment of wide necked bifurcation aneurysms: Intrasaccular flow disruption.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Review
- Endovascular treatment of wide-necked intracranial aneurysms using the Nautilus Intrasaccular System: initial case series of 41 patients at a single center.Journal of neurointerventional surgery · 2023Article
- Treatment of a ruptured shallow trilobed cerebral aneurysm with the novel saccular endovascular aneurysm lattice (SEAL) device: A case report with one year follow-up.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023Article
- Four-Year Follow-Up on the First-in-Human Experience With Nautilus Intrasaccular System Assisted Coiling for Unruptured Intracranial Aneurysms.Stroke (Hoboken, N.J.) · 2023Article
- Endovascular treatment of middle cerebral artery aneurysms: current status and future prospects.Frontiers in neurology · 2023Review
- Analysis of postoperative quality of life and prognosis of patients with intracranial aneurysm after nursing based on concept of time.American journal of translational research · 2023Article
- Will Coiling Survive through the Next Decade?Journal of clinical medicine · 2022Article
- Pre-Interventional 3D-Printing-Assisted Planning of Flow Disrupter Implantation for the Treatment of an Intracranial Aneurysm.Journal of clinical medicine · 2022Article
- Rabbit Elastase Aneurysm Model Mimics the Recurrence Rate of Human Intracranial Aneurysms following Platinum Coil Embolization.AJNR. American journal of neuroradiology · 2022Article
- The evolution of intracranial aneurysm treatment techniques and future directions.Neurosurgical review · 2022Review
Corrections and comments
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Authors and funding
11 authors at 10 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIntrasaccular aneurysm flow disruption represents an emerging endovascular approach to treat intracranial aneurysms. The purpose of this study was to determine the clinical and angiographic outcomes of using the LUNA aneurysm embolization system (AES) for treatment of intracranial aneurysms. MATERIALS AND
methodsThe LUNA AES Post-Market Clinical Follow-Up study is a prospective, multicenter, single-arm study that was designed to evaluate device safety and efficacy. Bifurcation and sidewall aneurysms were included. Aneurysm occlusion was assessed using the Raymond-Roy classification scale. Disability was assessed using the Modified Rankin Scale (mRS). Morbidity was defined as mRS >2 if baseline mRS ≤2, increase in mRS of 1 or more if baseline mRS >2, or mRS >2 if aneurysm was ruptured at baseline. Clinical and angiographic follow-up was conducted at 6, 12 and 36 months.
resultsSixty-three subjects with 64 aneurysms were enrolled. Most aneurysms were unruptured (60/63 (95.2%)); 49 were bifurcation or terminal (49/64 (76.6%)). Mean aneurysm size was 5.6±1.8 mm (range, 3.6-14.9 mm), and mean neck size was 3.8±1.0 mm (range, 1.9-8.7 mm). Though immediate postoperative adequate occlusion was low (11/63, 18%), adequate occlusion was achieved in 78.0% (46/59) and 79.2% (42/53) of the aneurysms at 12 months and 36 months, respectively. Four patients were retreated by the 12-month follow-up (4/63 (6.3%)) and three patients were retreated by the 36-month follow-up (3/63 (4.8%)). There were two major strokes (2/63 (3.2%)), one minor stroke (1/63 (1.6%)) and three incidents of intracranial hemorrhage in two subjects (2/63 (3.2%)) prior to the 12-month follow-up. There was one instance of mortality (1/63, 1.6%). Morbidity was 0% (0/63) and 1.8% (1/63) at the 12-month and 36-month follow-ups, respectively.
conclusionsLUNA AES is safe and effective for the treatment of bifurcation and sidewall aneurysms. CLINICAL
trial registrationISRCTN72343080; Results.
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