Evidence map›Paper›PMID 29669853›Full record

ArticleScience translational medicine2018

CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells.

Mohamed Abdel-Mohsen, Leticia Kuri-Cervantes, Judith Grau-Exposito, Adam M Spivak, Racheal A Nell, Costin Tomescu, Surya Kumari Vadrevu, Leila B Giron, Carla Serra-Peinado, Meritxell Genescà and 24 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 102 citations in OpenAlex.

  1. Review
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  15. Review
  16. Cure and Long-Term Remission Strategies.Methods in molecular biology (Clifton, N.J.) · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. The Contributions of Clinical Pharmacology to HIV Cure Research.Clinical pharmacology and therapeutics · 2021
    Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 12 institutions in 3 countries.

Mohamed Abdel-MohsenThe Wistar Institute, Philadelphia, PA 19104, USA.ORCID 0000-0002-9945-4314
Leticia Kuri-CervantesDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2432-9500
Judith Grau-ExpositoDepartment of Infectious Diseases, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona 08035, Spain.ORCID 0000-0001-9350-2429
Adam M SpivakUniversity of Utah School of Medicine, Salt Lake City, UT 84132, USA.ORCID 0000-0003-1815-7893
Racheal A NellUniversity of Utah School of Medicine, Salt Lake City, UT 84132, USA.ORCID 0000-0002-0324-7522
Costin TomescuThe Wistar Institute, Philadelphia, PA 19104, USA.
Surya Kumari VadrevuThe Wistar Institute, Philadelphia, PA 19104, USA.ORCID 0000-0003-1908-3611
Leila B GironThe Wistar Institute, Philadelphia, PA 19104, USA.ORCID 0000-0002-3898-5680
Carla Serra-PeinadoDepartment of Infectious Diseases, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona 08035, Spain.ORCID 0000-0003-1413-3990
Meritxell GenescàDepartment of Infectious Diseases, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona 08035, Spain.ORCID 0000-0001-6413-3812
Josep CastellvíDepartment of Pathology, Hospital Universitari Vall d´Hebrón, Barcelona 08035, Spain.ORCID 0000-0001-5745-9996
Guoxin WuMerck & Co. Inc., Kenilworth, NJ 07033, USA.
Perla M Del Rio EstradaInstituto Nacional de Enfermedades Respiratorias, Tlalpan 14080, Mexico City, Mexico.ORCID 0000-0003-3366-3268
Mauricio González-NavarroInstituto Nacional de Enfermedades Respiratorias, Tlalpan 14080, Mexico City, Mexico.ORCID 0000-0001-5247-2083
Kenneth LynnThe Wistar Institute, Philadelphia, PA 19104, USA.
Colin T KingEmory University, Atlanta, GA 30322, USA.
Sai VemulaMerck & Co. Inc., Kenilworth, NJ 07033, USA.
Kara CoxMerck & Co. Inc., Kenilworth, NJ 07033, USA.ORCID 0000-0002-5798-2944
Yanmin WanUniversity of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Qingsheng LiUniversity of Nebraska-Lincoln, Lincoln, NE 68588, USA.ORCID 0000-0003-4101-4073
Karam MounzerJonathan Lax Center, Philadelphia FIGHT, Philadelphia, PA 19107, USA.ORCID 0000-0001-8537-7103
Jay KostmanJonathan Lax Center, Philadelphia FIGHT, Philadelphia, PA 19107, USA.
Ian FrankDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mirko PaiardiniEmory University, Atlanta, GA 30322, USA.
Daria HazudaMerck & Co. Inc., Kenilworth, NJ 07033, USA.ORCID 0000-0002-6894-1056
Gustavo Reyes-TeránInstituto Nacional de Enfermedades Respiratorias, Tlalpan 14080, Mexico City, Mexico.
Douglas RichmanVeterans Affairs San Diego Healthcare System and University of California, San Diego, San Diego, CA 92093, USA.
Bonnie HowellMerck & Co. Inc., Kenilworth, NJ 07033, USA.ORCID 0000-0002-5915-9943
Pablo TebasDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5345-7942
Javier Martinez-PicadoIrsiCaixa AIDS Research Institute, Badalona 08916, Barcelona, Spain.
Vicente PlanellesUniversity of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Maria J BuzonDepartment of Infectious Diseases, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona 08035, Spain. montaner@wistar.org mariajose.buzon@vhir.org betts@pennmedicine.upenn.edu.ORCID 0000-0003-4427-9413
Michael R BettsDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. montaner@wistar.org mariajose.buzon@vhir.org betts@pennmedicine.upenn.edu.
Luis J MontanerThe Wistar Institute, Philadelphia, PA 19104, USA. montaner@wistar.org mariajose.buzon@vhir.org betts@pennmedicine.upenn.edu.ORCID 0000-0001-5799-6759
The Wistar Institute · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USUniversity of Pennsylvania · USVall d'Hebron Institut de Recerca · ESInstituto Nacional de Enfermedades Respiratorias · MXUniversity of Utah · USEmory University · USPhiladelphia Fight · USUniversity of Nebraska–Lincoln · USUniversitat de Vic - Universitat Central de Catalunya · ESVall d'Hebron Hospital Universitari · ESVA San Diego Healthcare System · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
University of Pennsylvania HIV Clinical Trials UnitUM1AI069534 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ian Frank, PABLO TEBAS · 2012 to 2026
$33.0M
Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
First-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5M
Collaboratory of AIDS Researchers for Eradication (CARE)UM1AI126619 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARGOLIS, DAVID M. · 2016 to 2020
$23.2M
Development of SMAC mimetics as latency-reversing agentsR01AI124843 · NIAID · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI CHANDA, SUMIT K, PLANELLES, VICENTE · 2016 to 2020
$3.4M
Viral control mechanisms of HIV-specific T cells in HIV-infected lymph nodeR01AI118694 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R · 2015 to 2019
$3.3M
Antiviral activity of Peg-IFN alpha in chronic HIV-1U01AI065279 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J · 2005 to 2009
$2.8M
NCATS NIH HHS UL1 TR002538NCI NIH HHS P30 CA010815NIAID NIH HHS P30 AI036214NIAID NIH HHS P30 AI045008NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI118694NIAID NIH HHS R01 AI124843NIAID NIH HHS R21 AI118411NIAID NIH HHS R21 AI129636NIAID NIH HHS U01 AI065279NIAID NIH HHS UM1 AI069534NIAID NIH HHS UM1 AI126619NIAID NIH HHS UM1 AI126620NIH HHS P51 OD011132NINDS NIH HHS R21 NS106970
6 · The paper itself

Abstract

The persistence of HIV reservoirs, including latently infected, resting CD4

Indexed as

Anti-Retroviral AgentsCD4-Positive T-LymphocytesHIV InfectionsHumansIn Vitro TechniquesLymphocytesReceptors, CCR4Receptors, CCR6Receptors, CXCR3Receptors, IgGAnti-Retroviral AgentsCCR4 protein, humanCCR6 protein, humanCXCR3 protein, humanReceptors, CCR4Receptors, CCR6Receptors, CXCR3Receptors, IgG

Identifiers

PMID29669853
PMCPMC6282755
OpenAlexW2800560571

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.