Evidence map›Paper›PMID 29669747›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

The Role of the Microglial Cx3cr1 Pathway in the Postnatal Maturation of Retinal Photoreceptors.

Andrew I Jobling, Michelle Waugh, Kirstan A Vessey, Joanna A Phipps, Lidia Trogrlic, Una Greferath, Samuel A Mills, Zhi L Tan, Michelle M Ward, Erica L Fletcher

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Ocular Vascular Diseases: From Retinal Immune Privilege to Inflammation.International journal of molecular sciences · 2023
    Review
  12. The Role of Microglia in Inherited Retinal Diseases.Advances in experimental medicine and biology · 2023
    Article
  13. Review
  14. Microglia in brain development and regeneration.Development (Cambridge, England) · 2022
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Andrew I JoblingDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville 3010 Victoria, Australia.ORCID 0000-0002-7827-3135
Michelle WaughDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville 3010 Victoria, Australia.
Kirstan A VesseyDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville 3010 Victoria, Australia.ORCID 0000-0003-1031-1964
Joanna A PhippsDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville 3010 Victoria, Australia.
Lidia TrogrlicDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville 3010 Victoria, Australia.ORCID 0000-0002-2127-7979
Una GreferathDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville 3010 Victoria, Australia.
Samuel A MillsDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville 3010 Victoria, Australia.
Zhi L TanDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville 3010 Victoria, Australia.
Michelle M WardDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville 3010 Victoria, Australia.ORCID 0000-0003-0153-0620
Erica L FletcherDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville 3010 Victoria, Australia e.fletcher@unimelb.edu.au.
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglia are the resident immune cells of the CNS, and their response to infection, injury and disease is well documented. More recently, microglia have been shown to play a role in normal CNS development, with the fractalkine-Cx3cr1 signaling pathway of particular importance. This work describes the interaction between the light-sensitive photoreceptors and microglia during eye opening, a time of postnatal photoreceptor maturation. Genetic removal of Cx3cr1 (

Indexed as

AnimalsCarrier ProteinsCX3C Chemokine Receptor 1Cytoskeletal ProteinsEyeEye ProteinsFemaleLightMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMicrogliaPhotoreceptor Cells, VertebratePhotoreceptor Connecting CiliumCarrier ProteinsCX3C Chemokine Receptor 1Cx3cr1 protein, mouseCytoskeletal ProteinsEye ProteinsProteinsRpgrip1 protein, mouseRPGR protein, mouseciliumCx3cr1fractalkinemicrogliaphotoreceptorretina

Identifiers

PMID29669747
PMCPMC6596015
OpenAlexW2802131709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.