Evidence map›Paper›PMID 29669734›Full record

ArticleMolecular & cellular proteomics : MCP2018

A Selective Extracellular Matrix Proteomics Approach Identifies Fibronectin Proteolysis by A Disintegrin-like and Metalloprotease Domain with Thrombospondin Type 1 Motifs (ADAMTS16) and Its Impact on Spheroid Morphogenesis.

Rahel Schnellmann, Ragna Sack, Daniel Hess, Douglas S Annis, Deane F Mosher, Suneel S Apte, Ruth Chiquet-Ehrismann

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
  2. Review
  3. An Overview of ADAMTS Proteases.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
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  11. Citrullination of matrisomal proteins in health and diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  12. Article
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  17. Review
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  19. Review
  20. Regulation of ADAMTS Proteases.Frontiers in molecular biosciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Rahel SchnellmannFrom the ‡Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; aptes@ccf.org rahel.schnellmann@fmi.ch.
Ragna SackFrom the ‡Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Daniel HessFrom the ‡Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Douglas S Annis‖Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin.
Deane F Mosher‖Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin.
Suneel S Apte¶Department of Biomedical Engineering (ND20), Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195; aptes@ccf.org rahel.schnellmann@fmi.ch.
Ruth Chiquet-EhrismannFrom the ‡Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Friedrich Miescher Institute · CHUniversity of Wisconsin–Madison · USCleveland Clinic Lerner College of Medicine · USUniversity of Basel · CH

Funding

VERSICAN PROTEOLYSIS AND REGULATION OF VASCULAR SMOOTH MUSCLEP01HL107147 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI LAUER, MARK E · 2011 to 2017
$16.1M
Extracellular matrix remodeling in ocular anterior segment developmentR01EY024943 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI APTE, SUNEEL S · 2015 to 2017
$1.1M
NEI NIH HHS R01 EY024943NHLBI NIH HHS P01 HL107147
6 · The paper itself

Abstract

Secreted and cell-surface proteases are major mediators of extracellular matrix (ECM) turnover, but their mechanisms and regulatory impact are poorly understood. We developed a mass spectrometry approach using a cell-free ECM produced

Indexed as

MorphogenesisProteolysis3T3 CellsADAMTS ProteinsAmino Acid SequenceAnimalsCollagenDogsExtracellular MatrixFibroblastsFibronectinsHEK293 CellsHumansMadin Darby Canine Kidney CellsMatrix Metalloproteinase 3MiceADAMTS16 protein, mouseADAMTS ProteinsCollagenFibronectinsMatrix Metalloproteinase 3PeptidesADAMTS proteaseExtracellular matrix*FibronectinMetalloproteasePost-translational modifications*Proteases*Protein Degradation*Proteolysis*

Identifiers

PMID29669734
PMCPMC6030725
OpenAlexW2800170195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.