ArticleJMIR research protocols2018
An Exercise Intervention to Unravel the Mechanisms Underlying Insulin Resistance in a Cohort of Black South African Women: Protocol for a Randomized Controlled Trial and Baseline Characteristics of Participants.
Article in JMIR research protocols, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity.Diabetologia · 2021Trial
- Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function.Scientific reports · 2020Trial
- Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Trial
- Exercise intervention alters HDL subclass distribution and function in obese women.Lipids in health and disease · 2018Trial
- Effects of Baobab fruit powder on gut and cardiometabolic health in obesity-Protocol for a randomised placebo-controlled trial.PloS one · 2025Article
- Pathophysiology of type 2 diabetes in sub-Saharan Africans.Diabetologia · 2022Review
- Changes in subcutaneous adipose tissue microRNA expression in response to exercise training in obese African women.Scientific reports · 2022Article
- A pilot investigation of genetic and epigenetic variation of FKBP5 and response to exercise intervention in African women with obesity.Scientific reports · 2022Article
- Perceptions and experiences of young Black South African women with obesity from a low socioeconomic community after following a 12-week structured exercise intervention.Frontiers in sports and active living · 2022Article
- β-cell function in black South African women: exploratory associations with insulin clearance, visceral and ectopic fat.Endocrine connections · 2021Article
- Circulating and Adipose Tissue Fatty Acid Composition in Black South African Women with Obesity: A Cross-Sectional Study.Nutrients · 2020Article
- Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
backgroundThe pathogenesis of type 2 diabetes (T2D) in black African women is complex and differs from that in their white counterparts. However, earlier studies have been cross-sectional and provide little insight into the causal pathways. Exercise training is consistently used as a model to examine the mechanisms underlying insulin resistance and risk for T2D.
objectiveThe objective of the study was to examine the mechanisms underlying the changes in insulin sensitivity and secretion in response to a 12-week exercise intervention in obese black South African (SA) women.
methodsA total of 45 obese (body mass index, BMI: 30-40 kg/m
resultsThe final sample included 20 exercise and 15 control participants. Baseline sociodemographics, cardiorespiratory fitness, anthropometry, cardiometabolic risk factors, physical activity, and diet did not differ between the groups (P>.05).
conclusionsThe study describes a research protocol for an exercise intervention to understand the mechanisms underlying insulin sensitivity and secretion in obese black SA women and aims to identify causal pathways underlying the high prevalence of insulin resistance and risk for T2D in black SA women, targeting specific areas for therapeutic intervention.
trial registrationPan African Clinical Trial Registry PACTR201711002789113; http://www.pactr.org/ATMWeb/ appmanager/atm/atmregistry?_nfpb=true&_pageLabel=portals_app_atmregistry_portal_page_13 (Archived by WebCite at http://www.webcitation.org/6xLEFqKr0).
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