ArticleCell reports2018
Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice.
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Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Kappa opioid receptors in excitatory spinal neurons gate acute pain: evidence from mouse and human.bioRxiv : the preprint server for biology · 2026Article
- Discovery of a Potent Small Molecule Antagonist of GRPR for the Treatment of Pruritus.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Article
- Genetic Variation A118G in the OPRM1 Gene Underlies the Dimorphic Response to Epidural Opioid-Induced Itch.Neuroscience bulletin · 2025Article
- Identification of VGLUT3-expressing LTMRs-recruited spinal circuits for itch inhibition.Molecular brain · 2025Article
- Meta-Analysis of Randomized Controlled Trials on Gamma-Aminobutyric Acid Analogues and Opioid-Based Therapies for CKD-Associated Pruritus.Kidney international reports · 2025Article
- Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord.Nature communications · 2025Article
- Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets.Acta pharmacologica Sinica · 2025Review
- Opioid receptor signaling throughout ontogeny: Shaping neural and behavioral trajectories.Neuroscience and biobehavioral reviews · 2025Review
- Kappa opioids inhibit spinal output neurons to suppress itch.Science advances · 2024Article
- Identification of a convergent spinal neuron population that encodes itch.bioRxiv : the preprint server for biology · 2023Article
- Excitatory Projections from the Prefrontal Cortex to Nucleus Accumbens Core D1-MSNs and κ Opioid Receptor Modulate Itch-Related Scratching Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Delta-Opioid Receptor Bidirectionally Modulates Itch.The journal of pain · 2023Article
- A non-canonical retina-ipRGCs-SCN-PVT visual pathway for mediating contagious itch behavior.Cell reports · 2022Article
- The translational revolution of itch.Neuron · 2022Review
- Molecular Genetics of Kappa Opioids in Pain and Itch Sensations.Handbook of experimental pharmacology · 2022Review
- Article
- A neuropeptide code for itch.Nature reviews. Neuroscience · 2021Review
- Antipruritic Effect of Nalbuphine, a Kappa Opioid Receptor Agonist, in Mice: A Pan Antipruritic.Molecules (Basel, Switzerland) · 2021Article
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Authors and funding
21 authors at 3 institutions in 3 countries.
Admire MunanairiCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Xian-Yu LiuCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Devin M BarryCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Qianyi YangCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jun-Bin YinCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anatomy and K. K. Leung Brain Research Centre, The Fourth Military Medical University, 710032 Xi'an, PRC.
Hua JinCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hui LiCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anatomy and K. K. Leung Brain Research Centre, The Fourth Military Medical University, 710032 Xi'an, PRC.
Qing-Tao MengCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jia-Hang PengCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Zhen-Yu WuCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anatomy and K. K. Leung Brain Research Centre, The Fourth Military Medical University, 710032 Xi'an, PRC.
Jun YinCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Xuan-Yi ZhouCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
Li WanCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anatomy and K. K. Leung Brain Research Centre, The Fourth Military Medical University, 710032 Xi'an, PRC.
Ping MoCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anatomy and K. K. Leung Brain Research Centre, The Fourth Military Medical University, 710032 Xi'an, PRC.
Seungil KimCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
Fu-Quan HuoCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA.
Joseph JeffryCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yun-Qing LiDepartment of Anatomy and K. K. Leung Brain Research Centre, The Fourth Military Medical University, 710032 Xi'an, PRC; Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, PRC.
Rita BardoniDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy.
Michael R BruchasDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
Zhou-Feng ChenCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: chenz@wustl.edu.
Washington University in St. Louis · USAir Force Medical University · CNUniversity of Modena and Reggio Emilia · IT
Funding
BIOMEDICAL RESEARCH TRAINING IN DRUG ABUSET32DA007261 · NIDA · WASHINGTON UNIVERSITY · PI ARPANA AGRAWAL, Jose A Moron-Concepcion · 1991 to 2026
$8.8MMOLECULAR MECHANISMS OF THE ITCH SENSATION IN THE SPINAL CORDR01AR056318 · NIAMS · WASHINGTON UNIVERSITY · PI CHEN, ZHOUFENG · 2009 to 2018
$4.5MDISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCER37DA033396 · NIDA · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2018 to 2026
$3.8MMECHANISMS OF DESENSITIZATION OF MOR1D-GRPR CROSSTALKR01DA037261 · NIDA · WASHINGTON UNIVERSITY · PI CHEN, ZHOUFENG · 2015 to 2019
$2.1MDISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCER01DA033396 · NIDA · WASHINGTON UNIVERSITY · PI BRUCHAS, MICHAEL R. · 2013 to 2017
$1.9MUNDERSTANDING MECHANISMS THAT BLOCK GRPR-MEDIATED CHRONIC ITCHR01NS094344 · NINDS · WASHINGTON UNIVERSITY · PI CHEN, ZHOUFENG · 2015 to 2019
$1.8MTHE ROLE OF PKA IN GRPR DESENSITIZATIONR21NS088861 · NINDS · WASHINGTON UNIVERSITY · PI CHEN, ZHOUFENG · 2015 to 2016
$419kA Novel Approach to Identify the Mediators in Chronic ItchR56AR064294 · NIAMS · WASHINGTON UNIVERSITY · PI CHEN, ZHOUFENG · 2014 to 2015
$419kNIAMS NIH HHS R01 AR056318NIAMS NIH HHS R56 AR064294NIDA NIH HHS R01 DA033396NIDA NIH HHS R01 DA037261NIDA NIH HHS R37 DA033396NIDA NIH HHS T32 DA007261NINDS NIH HHS R01 NS094344NINDS NIH HHS R21 NS088861
Abstract
Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive. Here, we find that KOR and gastrin-releasing peptide receptor (GRPR) overlap in the spinal cord, and KOR activation attenuated GRPR-mediated histamine-independent acute and chronic itch in mice. Notably, canonical KOR-mediated G
Indexed as
Signal TransductionAnimalsCell MembraneChloroquineGTP-Binding Protein alpha Subunits, Gi-GoHEK293 CellsHumansMiceMice, Inbred C57BLMice, KnockoutPhosphorylationProtein Kinase C-deltaPruritusReceptors, BombesinReceptors, Opioid, kappaRNA InterferenceChloroquineGTP-Binding Protein alpha Subunits, Gi-GoPrkcd protein, mouseProtein Kinase C-deltaReceptors, BombesinReceptors, Opioid, kappaRNA, Small InterferingType C PhospholipasesGPCR cross-signalingGRPRitchKORmousephosphorylationPKCspinal cord
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.