ArticleThe New England journal of medicine2018
Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain.
Article in The New England journal of medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06098872 (Pilot Study on the Efficacy of MEK1/MEK2 Inhibitor Trametinib in Patients With Surgical Unruptured Arteriovenous Malformations), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study on the Efficacy of MEK1/MEK2 Inhibitor Trametinib in Patients With Surgical Unruptured Arteriovenous Malformations
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recurrence of arteriovenous malformations of the brain after complete surgical resection. Kuopio University Hospital experience and systematic review of the literature.Neurosurgical review · 2023Pooled it
- M2 Macrophage Polarization Characterizes an Immunosuppressive Microenvironment in Extracranial Arteriovenous Malformations.Biomedicines · 2026Article
- Lymphatic Malformations With Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- De novo twig-like middle cerebral artery after suspected M1 dissection in early childhood with coexisting KRAS-mutated brain arteriovenous malformation: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Review
- Defining the transcriptome of PIK3CA-altered cells in a human capillary malformation using single cell long-read sequencing.Scientific reports · 2024Article
- Peripheral macrophages in the development and progression of structural cerebrovascular pathologies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
- SomaticStroke and vascular neurology · 2023Article
- ErbB signaling is a potential therapeutic target for vascular lesions with fibrous component.eLife · 2023Article
- RAS pathway: The new frontier of brain mosaicism in epilepsy.Neurobiology of disease · 2023Review
- Current perspectives and trends in the treatment of brain arteriovenous malformations: a review and bibliometric analysis.Frontiers in neurology · 2023Article
- Molecular and genetic mechanisms in brain arteriovenous malformations: new insights and future perspectives.Neurosurgical review · 2022Review
- Recalibrating vascular malformations and mechanotransduction by pharmacological intervention.The Journal of clinical investigation · 2022Article
- Neurovascular disease: 2022 update.Free neuropathology · 2022Article
- Targeted treatment of vascular anomalies.International journal of women's dermatology · 2021Review
- Sonic hedgehog is expressed in human brain arteriovenous malformations and induces arteriovenous malformations in vivo.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Bilateral optic disc pits in a pediatric patient with Cobb syndrome.American journal of ophthalmology case reports · 2020Article
- Clinical and imaging features of intraosseous arteriovenous malformations in jaws: a 15-year experience of single centre.Scientific reports · 2020Article
- Germline and sporadic cancers driven by the RAS pathway: parallels and contrasts.Annals of oncology : official journal of the European Society for Medical Oncology · 2020Review
- Exome sequencing reveals a novel variant inJournal of neurointerventional surgery · 2020Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.