ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2018
Are Trends in Dementia Incidence Associated With Compression in Morbidity? Evidence From The Framingham Heart Study.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Systematic review of the association between life-course socioeconomic status and late-life cognitive decline.Journal of epidemiology and community health · 2026Pooled it
- The principles of Population-Level Approaches to Dementia Risk Reduction (PLADRR).PLoS medicine · 2026Article
- Thirty-seven-year trends in the prevalence, incidence, and prognosis of dementia in a Japanese community: the Hisayama study.Alzheimer's research & therapy · 2025Article
- Secular trends in incidence, survival, and health status at diagnosis of dementia in Sweden, 2007-2022.Alzheimer's research & therapy · 2025Article
- Predicting sojourn times across dementia disease stages, institutionalization, and mortality.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Compression and Expansion of Morbidity—Secular Trends Among Cohorts of the Same AgeDeutsches Arzteblatt international · 2022Review
- An Evolution-Based Model of Causation for Aging-Related Diseases and Intrinsic Mortality: Explanatory Properties and Implications for Healthy Aging.Frontiers in public health · 2022Article
- Secular trends in prevalent mild cognitive impairment: Data from the Swedish population-based study Good Aging in Skåne.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- A New Look at Cohort Trend and Underlying Mechanisms in Cognitive Functioning.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Cohort and Period Effects as Explanations for Declining Dementia Trends and Cognitive Aging.Population and development review · 2021Article
- Dementia remains the major predictor of death among octogenarians. A study of two population cohorts of 85-year-olds examined 22 years apart.European journal of epidemiology · 2021Article
- Heterogeneity in Reports of Dementia Disease Duration and Severity: A Review of the Literature.Journal of Alzheimer's disease : JAD · 2021Review
- Secular trends of mortality and dementia-free life expectancy over a 10-year period in France.European journal of epidemiology · 2019Article
- Cohort Differences in Cognitive Impairment and Cognitive Decline Among Mexican-Americans Aged 75 Years or Older.American journal of epidemiology · 2019Article
- Introduction to a Supplement on Population Level Trends in Dementia: Causes, Disparities, and Projections.The journals of gerontology. Series B, Psychological sciences and social sciences · 2018Article
- The Joint Impact of Age at Death and Dementia on Long-Term Care Use in the Last Years of Life: Changes From 1996 to 2013 in Finland.Gerontology & geriatric medicineArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Objectives: Several epidemiological studies suggest declining trends in dementia over the last three decades with both decreasing age-specific prevalence and incidence. There is limited data on whether this delayed clinical onset is accompanied by a shorter postdiagnosis survival. Methods: A total of 5,205 participants from the Framingham Original and Offspring cohorts were studied. Four epochs were considered from 1977-1984 to 2004-2008. Gender and education adjusted 5-year mortality risks were estimated using delayed entry Cox models with the earliest epoch as reference category. Stratified analyses by sex, education, and age were undertaken. A nested case control study of 317 dementia cases and 317 controls matched on age, gender and epoch was initiated. Results: In the whole sample, 5-year mortality risk has decreased with time, it was 33% lower in the last epoch compared to the earliest. In the 317 persons who developed dementia, age at onset increased (1.5 years/epoch), and years alive with dementia decreased (1 year/epoch) over time. We observed however, a decreased adjusted relative mortality risk (by 18%) in persons with dementia in 1986-1991 compared to 1977-1983 and no significant change from then to the latest epoch. The nested case control study suggested in matched controls that 5-year mortality relative risk had increased by 60% in the last epoch compared to Epoch 1. Discussion: In the FHS, in the last 30 years, disease duration in persons with dementia has decreased. However, age-adjusted mortality risk has slightly decreased after 1977-1983. Consequences of such trends on dementia prevalence should be investigated.
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