ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2018
The Impact of Changes in Population Health and Mortality on Future Prevalence of Alzheimer's Disease and Other Dementias in the United States.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of hypertension prevention and modification on dementia burden: A systematic review of economic studies.The journal of prevention of Alzheimer's disease · 2025Pooled it
- Cognitive and biological effects of citrus phytochemicals in subjective cognitive decline: a 36-week, randomized, placebo-controlled trial.Nutrition journal · 2022Trial
- Outdoor extreme heat-related dementia risk and the role of socioeconomic disparities: evidence from 20 years of data on US older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The value of timely treatment with anti-amyloid therapy for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Mild Cognitive Impairment Diagnosis and Care Algorithms and the Role of Digital Interventions: Expert Consensus.CNS neuroscience & therapeutics · 2026Review
- Care Partner Perspectives on Hypertension Management in Alzheimer Disease and Related Dementias in an Online Forum: Qualitative Thematic Analysis.JMIR nursing · 2026Article
- Older Americans' Attitudes Toward Caregiving Cost Responsibility and Long-Term Care Access and Costs by Caregiver Status.Journal of the American Geriatrics Society · 2026Article
- Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The cost of dementia in the United States in 2026.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Epigenetic g predicts cognitive function in a diverse, nationally representative sample of older adults.Clinical epigenetics · 2026Article
- Forecast of dementia prevalence in Germany and subnational regions until 2060 using microsimulation.European journal of epidemiology · 2026Article
- Circulating Biomarkers of Neurodegeneration and All-Cause and Dementia-Specific Mortality.Neurology · 2026Article
- Neighborhood social environment and physical activity among persons living with dementia.The Gerontologist · 2026Article
- The sociological stakes of attitudes toward the families and care of older adults with dementia.Sociological forum (Randolph, N.J.) · 2026Article
- Association between cumulative average BMI and cognitive decline: a 24-year cohort study.Journal of neurology · 2026Article
- Insomnia-Related Metabolomic Profiles Reflect Antioxidant Deficits and Relate to Cognitive Decline Through a Metabolic Risk Score in HCHS/SOL.medRxiv : the preprint server for health sciences · 2026Article
- Demographic Change and the Future of Austria's Long-Term-Care Allowance: A Dynamic Microsimulation Study.Healthcare (Basel, Switzerland) · 2025Article
- Attenuation of blood-brain barrier dysfunction by functionalized gold nanoparticles against amyloid-β peptide in an Alzheimer's disease-on-a-chip model.Materials today. Bio · 2025Article
- Lifetime burden of prescription medication for insomnia in middle-aged and older adults in the US: a microsimulation study.Lancet regional health. Americas · 2025Article
- Personhood Beliefs in Dementia Care: Influences of Race, Socioeconomic Factors, and Social Vulnerability.International journal of environmental research and public health · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Objectives: We assessed potential benefits for older Americans of reducing risk factors associated with dementia. Methods: A dynamic simulation model tracked a national cohort of persons 51 and 52 years of age to project dementia onset and mortality in risk reduction scenarios for diabetes, hypertension, and dementia. Results: We found reducing incidence of diabetes by 50% did not reduce number of years a person ages 51 or 52 lived with dementia and increased the population ages 65 and older in 2040 with dementia by about 115,000. Eliminating hypertension at middle and older ages increased life expectancy conditional on survival to age 65 by almost 1 year, however, it increased years living with dementia. Innovation in treatments that delay onset of dementia by 2 years increased longevity, reduced years with dementia, and decreased the population ages 65 and older in 2040 with dementia by 2.2 million. Conclusions: Prevention of chronic disease may generate health and longevity benefits but does not reduce burden of dementia. A focus on treatments that provide even short delays in onset of dementia can have immediate impacts on longevity and quality of life and reduce the number of Americans with dementia over the next decades.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.