ArticleToxicological sciences : an official journal of the Society of Toxicology2018
Hydroxylated-Graphene Quantum Dots Induce DNA Damage and Disrupt Microtubule Structure in Human Esophageal Epithelial Cells.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Therapeutic Potential of Graphene Quantum Dots on Pterygium Cells.Investigative ophthalmology & visual science · 2025Article
- Exploring In Vivo Pulmonary and Splenic Toxicity Profiles of Silicon Quantum Dots in Mice.Materials (Basel, Switzerland) · 2024Article
- Photothermal therapy using graphene quantum dots.APL bioengineering · 2023Review
- Molecular Dynamics Simulation of the Interaction between Graphene Oxide Quantum Dots and DNA Fragment.Materials (Basel, Switzerland) · 2022Article
- Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile.Particle and fibre toxicology · 2022Article
- Article
- Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials.Scientific data · 2021Article
- Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia.Particle and fibre toxicology · 2020Article
- The Differential Effect of Carbon Dots on Gene Expression and DNA Methylation of Human Embryonic Lung Fibroblasts as a Function of Surface Charge and Dose.International journal of molecular sciences · 2020Article
- Toxicology data of graphene-family nanomaterials: an update.Archives of toxicology · 2020Review
- Understanding the Nano-Bio Interactions and the Corresponding Biological Responses.Frontiers in chemistry · 2020Review
- Antioxidant Activity of Graphene Quantum Dots Prepared in Different Electrolyte Environments.Nanomaterials (Basel, Switzerland) · 2019Article
- Recent advances in graphene-based nanomaterials: properties, toxicity and applications in chemistry, biology and medicine.Mikrochimica acta · 2019Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graphene quantum dots (GQDs) have attracted significant interests due to their unique chemical and physical properties. In this study, we investigated the potential effects of hydroxyl-modified GQDs (OH-GQDs) on the human esophageal epithelial cell line HET-1A. Our data revealed significant cytotoxicity of OH-GQDs which decreased the viability of HET-1A in a dose and time-dependent manner. The moderate concentration (25 or 50 µg/ml) of OH-GQDs significantly blocked HET-1A cells in G0/G1 cell cycle phase. An increased percentage of γH2AX-positive and genomically unstable cells were also detected in cells treated with different doses of OH-GQDs (25, 50, and 100 µg/ml). Microarray data revealed that OH-GQDs treatment down-regulated genes related to DNA damage repair, cell cycle regulation and cytoskeleton signal pathways indicating a novel role of OH-GQDs. Consistent with the microarray data, OH-GQDs disrupted microtubule structure and inhibited microtubule regrowth around centrosomes in HET-1A cells. In conclusion, our findings provide important evidence for considering the application of OH-GQDs in biomedical fields.
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