ArticleJournal of the American Medical Informatics Association : JAMIA2018
Does health informatics have a replication crisis?
Article in Journal of the American Medical Informatics Association : JAMIA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- AI Quality Standards in Health Care: Rapid Umbrella Review.Journal of medical Internet research · 2024Pooled it
- The Reporting Quality of Machine Learning Studies on Pediatric Diabetes Mellitus: Systematic Review.Journal of medical Internet research · 2024Pooled it
- eHealth tools to assess the neurological function for research, in absence of the neurologist - a systematic review, part I (software).Journal of neurology · 2024Pooled it
- Pooled it
- The Personalization of Conversational Agents in Health Care: Systematic Review.Journal of medical Internet research · 2019Pooled it
- Conversational agents in healthcare: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2018Pooled it
- Logic Models on Health Information Technology-Related Interventions: Scoping Review Across Disciplines.JMIR medical informatics · 2026Article
- Financial performance of hospitals in Europe - a scoping review.BMC health services research · 2025Article
- Then a miracle occurs: cause, effect, and the heterogeneity of criminal justice research.Journal of experimental criminology · 2025Article
- Glucagon-Like Peptide 1 Receptor Agonists and Chronic Lower Respiratory Disease Among Type 2 Diabetes Patients: Replication and Reliability Assessment Across a Research Network.Pharmacoepidemiology and drug safety · 2025Article
- Unlocking artificial intelligence, machine learning and deep learning to combat therapeutic resistance in metastatic castration-resistant prostate cancer: a comprehensive review.Ecancermedicalscience · 2025Review
- The challenges of replication: A worked example of methods reproducibility using electronic health record data.PloS one · 2025Article
- Article
- Pneumonia diagnosis performance in the emergency department: a mixed-methods study about clinicians' experiences and exploration of individual differences and response to diagnostic performance feedback.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Article
- Article
- Replicability and reproducibility of predictive models for diagnosis of depression among young adults using Electronic Health Records.Diagnostic and prognostic research · 2023Article
- Adoption of a COVID-19 Contact Tracing App by Czech Youth: Cross-Cultural Replication Study.JMIR human factors · 2023Article
- Reproducible variability: assessing investigator discordance across 9 research teams attempting to reproduce the same observational study.Journal of the American Medical Informatics Association : JAMIA · 2023Observational
- Healthcare knowledge graph construction: A systematic review of the state-of-the-art, open issues, and opportunities.Journal of big data · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Many research fields, including psychology and basic medical sciences, struggle with poor reproducibility of reported studies. Biomedical and health informatics is unlikely to be immune to these challenges. This paper explores replication in informatics and the unique challenges the discipline faces. Methods: Narrative review of recent literature on research replication challenges. Results: While there is growing interest in re-analysis of existing data, experimental replication studies appear uncommon in informatics. Context effects are a particular challenge as they make ensuring replication fidelity difficult, and the same intervention will never quite reproduce the same result in different settings. Replication studies take many forms, trading-off testing validity of past findings against testing generalizability. Exact and partial replication designs emphasize testing validity while quasi and conceptual studies test generalizability of an underlying model or hypothesis with different methods or in a different setting. Conclusions: The cost of poor replication is a weakening in the quality of published research and the evidence-based foundation of health informatics. The benefits of replication include increased rigor in research, and the development of evaluation methods that distinguish the impact of context and the nonreproducibility of research. Taking replication seriously is essential if biomedical and health informatics is to be an evidence-based discipline.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.