ArticleGigaScience2018
Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization.
Article in GigaScience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed, 155 citations in OpenAlex.
- Integrating landscape genomics and machine learning to analyze the genetic structure and specific molecular markers of Chinese dairy goats (Capra hircus).Journal of animal science and biotechnology · 2026Article
- A Functional SNP in the Promoter Region of Ovine IDO2 Associated With Melatonin Levels via Affecting Transcription Activity by CLOCK.Animal genetics · 2026Article
- Identification and functional assessment of CDSN gene variants associated with horn phenotypes in sheep.BMC genomics · 2026Article
- Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Functional analysis of the FGF2 gene in horn development in sheep and identification of key regulatory variants.BMC genomics · 2025Article
- Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes.bioRxiv : the preprint server for biology · 2025Article
- Association Analysis of SNPs inAnimals : an open access journal from MDPI · 2025Article
- Screening of molecular markers associated with hornless traits in Qira black sheep.BMC genomics · 2025Article
- Single nucleotide polymorphism-based analysis of linkage disequilibrium and runs of homozygosity patterns of indigenous sheep in the southern Taklamakan desert.BMC genomics · 2025Article
- Significance of KLK7 expression, polymorphisms, and function in sheep horn growth.BMC genomics · 2025Article
- Association analysis of single nucleotide polymorphisms in the LIFR gene with lambing number in sheep.Frontiers in veterinary science · 2025Article
- Single-cell transcriptome analysis reveals elongation and ossification characteristics of antlers.Frontiers in veterinary science · 2025Article
- Tissue-specific expression and functional role of keratin 1 in sheep horn development.Frontiers in veterinary science · 2025Article
- Revealing the genetic basis of coat color in Tibetan sheep through selective sweep and transcriptomic analyses.Frontiers in veterinary science · 2025Article
- Identification ofInternational journal of molecular sciences · 2024Article
- Genome-Wide Association Analyses and Population Verification Highlight the Potential Genetic Basis of Horned Morphology during Polled Selection in Tibetan Sheep.Animals : an open access journal from MDPI · 2024Article
- Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep.Genomics, proteomics & bioinformatics · 2024Article
- Genomic structural variation contributes to evolved changes in gene expression in high-altitude Tibetan sheep.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits.Genetics, selection, evolution : GSE · 2024Article
- Comparative whole-genome resequencing to uncover selection signatures linked to litter size in Hu Sheep and five other breeds.BMC genomics · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Animal domestication has been extensively studied, but the process of feralization remains poorly understood. Results: Here, we performed whole-genome sequencing of 99 sheep and identified a primary genetic divergence between 2 heterogeneous populations in the Tibetan Plateau, including 1 semi-feral lineage. Selective sweep and candidate gene analysis revealed local adaptations of these sheep associated with sensory perception, muscle strength, eating habit, mating process, and aggressive behavior. In particular, a horn-related gene, RXFP2, showed signs of rapid evolution specifically in the semi-feral breeds. A unique haplotype and repressed horn-related tissue expression of RXFP2 were correlated with higher horn length, as well as spiral and horizontally extended horn shape. Conclusions: Semi-feralization has an extensive impact on diverse phenotypic traits of sheep. By acquiring features like those of their wild ancestors, semi-feral sheep were able to regain fitness while in frequent contact with wild surroundings and rare human interventions. This study provides a new insight into the evolution of domestic animals when human interventions are no longer dominant.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.