ArticleMolecular biology and evolution2018
Evolution of Genome Architecture in Archaea: Spontaneous Generation of a New Chromosome in Haloferax volcanii.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The halophilic archaeonMicrobiology spectrum · 2026Article
- Article
- Genomic re-sequencing reveals mutational divergence across genetically engineered strains of model archaea.mSystems · 2025Article
- Global dominance of Haloquadratum walsbyi by a single genomovar with distinct gene content and viral cohorts from close relatives.The ISME journal · 2025Article
- Provirus deletion frommicroLife · 2025Article
- Development of a genetic system forApplied and environmental microbiology · 2024Article
- Form and function of archaeal genomes.Biochemical Society transactions · 2022Article
- Article
- Isolation of a virus causing a chronic infection in the archaeal model organismProceedings of the National Academy of Sciences of the United States of America · 2022Article
- What makes a megaplasmid?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Review
- Archaeal DNA Replication.Annual review of microbiology · 2020Review
- Whole-genome comparison between the type strain of Halobacterium salinarum (DSM 3754MicrobiologyOpen · 2020Article
- Article
- Gene Expression ofInternational journal of molecular sciences · 2019Article
- Haloarchaeal Carotenoids: Healthy Novel Compounds from Extreme Environments.Marine drugs · 2019Review
- Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly.Science (New York, N.Y.) · 2019Article
- Replicate Once Per Cell Cycle: Replication Control of Secondary Chromosomes.Frontiers in microbiology · 2018Review
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Authors and funding
9 authors.
Funding
Abstract
The common ancestry of archaea and eukaryotes is evident in their genome architecture. All eukaryotic and several archaeal genomes consist of multiple chromosomes, each replicated from multiple origins. Three scenarios have been proposed for the evolution of this genome architecture: 1) mutational diversification of a multi-copy chromosome; 2) capture of a new chromosome by horizontal transfer; 3) acquisition of new origins and splitting into two replication-competent chromosomes. We report an example of the third scenario: the multi-origin chromosome of the archaeon Haloferax volcanii has split into two elements via homologous recombination. The newly generated elements are bona fide chromosomes, because each bears "chromosomal" replication origins, rRNA loci, and essential genes. The new chromosomes were stable during routine growth but additional genetic manipulation, which involves selective bottlenecks, provoked further rearrangements. To the best of our knowledge, rearrangement of a naturally evolved prokaryotic genome to generate two new chromosomes has not been described previously.
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