ArticleThe Journal of infectious diseases2018
Secondary Bacterial Pneumonia by Staphylococcus aureus Following Influenza A Infection Is SaeR/S Dependent.
Article in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Molecular characterization of PVL-positive methicillin-resistant Staphylococcus aureus (MRSA) isolates from skin and soft tissue infections in Alexandria, Egypt.Archives of microbiology · 2026Article
- Addition of lactoferrin increases efficacy of three Kayviruses and limits the inflammatory response in pulmonary epithelial cells.Applied microbiology and biotechnology · 2026Article
- A comprehensive review of emerging therapeutic strategies against methicillin-resistantFrontiers in microbiology · 2026Review
- Lung surfactant reducesMicrobiology spectrum · 2025Article
- Article
- Efficacy of Three Kayviruses AgainstAntibiotics (Basel, Switzerland) · 2025Article
- Article
- SaeR as a novel target for antivirulence therapy againstEmerging microbes & infections · 2023Article
- TheiScience · 2023Article
- Microbial and Immune Regulation of the Gut-Lung Axis during Viral-Bacterial Coinfection.Journal of bacteriology · 2023Review
- Antibacterial Activity ofInfection and drug resistance · 2023Article
- The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia.Cell reports · 2022Article
- Article
- Successful treatment of pleural empyema and necrotizing pneumonia caused by methicillin-resistantFrontiers in pediatrics · 2022Article
- Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic Review.Antibiotics (Basel, Switzerland) · 2021Review
- Altered Signal Transduction in the Immune Response to Influenza Virus andInternational journal of molecular sciences · 2021Review
- Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge.Infection control and hospital epidemiology · 2021Observational
- Article
- Aspartic Acid Residue 51 of SaeR Is Essential forFrontiers in microbiology · 2018Article
- Severe Pneumonia Caused by Coinfection With Influenza Virus Followed by Methicillin-ResistantFrontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Staphylococcus aureus is a predominant cause of fatal pneumonia following influenza A virus (IAV) infection. Herein we investigate the influence of antecedent IAV infection on S. aureus virulence gene expression. Using a murine model, comparing the USA300 and USA300ΔsaeR/S strains, we demonstrate that S. aureus pathogenesis following IAV infection is SaeR/S dependent. Furthermore, we show that IAV modulates the lung environment to rapidly up-regulate S. aureus virulence factors containing the SaeR-binding domain. Data demonstrate that the pathogen response to IAV infection impacts host outcome and provides evidence that the ability of S. aureus to sense and respond to the lung environment determines severity of pneumonia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.