ArticlePathogens and disease2018
The activity of bacterial peptidylarginine deiminase is important during formation of dual-species biofilm by periodontal pathogen Porphyromonas gingivalis and opportunistic fungus Candida albicans.
Article in Pathogens and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Pathogenesis ofFrontiers in cellular and infection microbiology · 2026Review
- Peptidylarginine Deiminases: An Overview of Recent Advances in Citrullination Research.International journal of molecular sciences · 2025Review
- Synergistic effects ofFrontiers in cellular and infection microbiology · 2025Article
- Potential roles and mechanisms of bacterial peptidylarginine deiminase in dental biofilm mediated byJournal of oral microbiology · 2025Review
- Article
- The Impact ofInternational journal of molecular sciences · 2024Article
- Host cell responses toFrontiers in cellular and infection microbiology · 2024Article
- Identification of a new genetic variant (G231N, E232T, N235D) of peptidylarginine deiminase fromFrontiers in immunology · 2024Article
- Article
- Functional annotation of uncharacterized proteins from Fusobacterium nucleatum: identification of virulence factors.Genomics & informatics · 2023Article
- Mechanisms ofJournal of oral microbiology · 2023Review
- Antifungal Susceptibility ofAntibiotics (Basel, Switzerland) · 2022Article
- Co-Infection of OralMedicina (Kaunas, Lithuania) · 2022Article
- Inhibition ofSaudi journal of biological sciences · 2022Article
- In it together: Candida-bacterial oral biofilms and therapeutic strategies.Environmental microbiology reports · 2022Review
- Fungi-A Component of the Oral Microbiome Involved in Periodontal Diseases.Advances in experimental medicine and biology · 2022Article
- Recent Advances and Opportunities in the Study ofFrontiers in cellular and infection microbiology · 2022Review
- Proteinous Components of Neutrophil Extracellular Traps Are Arrested by the Cell Wall Proteins ofCells · 2021Article
- Understanding Human Microbiota Offers Novel and Promising Therapeutic Options againstPathogens (Basel, Switzerland) · 2021Review
- The Role ofFrontiers in cellular and infection microbiology · 2021Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Porphyromonas gingivalis, an anaerobic Gram-negative bacterium critically involved in the development of human periodontitis, belongs to the late colonizers of the oral cavity. The success of this pathogen in the host colonization and infection results from the presence of several virulence factors, including extracellular peptidylarginine deiminase (PPAD), an enzyme that converts protein arginine residues to citrullines. A common opportunistic fungal pathogen of humans, Candida albicans, is also frequently identified among microorganisms that reside at subgingival sites. The aim of the current work was to verify if protein citrullination can influence the formation of mixed biofilms by both microorganisms under hypoxic and normoxic conditions. Quantitative estimations of the bacterial adhesion to fungal cells demonstrated the importance of PPAD activity in this process, since the level of binding of P. gingivalis mutant strain deprived of PPAD was significantly lower than that observed for the wild-type strain. These results were consistent with mass spectrometric detection of the citrullination of selected surface-exposed C. albicans proteins. Furthermore, a viability of P. gingivalis cells under normoxia increased in the presence of fungal biofilm compared with the bacteria that formed single-species biofilm. These findings suggest a possible protection of these strict anaerobes under unfavorable aerobic conditions by C. albicans during mixed biofilm formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.